Title:
薬物の薬物動態を改善するためのアンチセンス酵素インヒビター
Document Type and Number:
Japanese Patent JP2004523465
Kind Code:
A
Abstract:
A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.
Inventors:
Ibersen, Patrick El.
Application Number:
JP2001583754A
Publication Date:
August 05, 2004
Filing Date:
May 16, 2001
Export Citation:
Assignee:
AVA I By Offeroma, Inc.
International Classes:
C12N15/09; A61K31/167; A61K31/337; A61K31/515; A61K31/565; A61K31/7048; A61K45/00; A61K48/00; A61P3/00; A61P5/24; A61P25/20; A61P29/00; A61P31/04; A61P43/00; C07H21/04; C12N15/113; A61K38/00; (IPC1-7): A61K48/00; A61K31/167; A61K31/515; A61K31/565; A61K31/7048; A61K45/00; A61P3/00; A61P5/24; A61P25/20; A61P29/00; A61P31/04; A61P43/00; C07H21/04
Foreign References:
| WO1998000172A2 | 1998-01-08 | |||
| WO2000002588A1 | 2000-01-20 | |||
| WO2000017366A2 | 2000-03-30 | |||
| WO2000020432A1 | 2000-04-13 | |||
| WO2000024885A2 | 2000-05-04 | |||
| WO2000045167A2 | 2000-08-03 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita