Title:
ANTISENSE MODULATION OF CLUSTERIN EXPRESSION
Document Type and Number:
Japanese Patent JP2014027936
Kind Code:
A
Abstract:
To provide compositions and methods for modulating clusterin expression.
Provided are antisense compounds for modulating expression of clusterin. Also provided are compositions comprising the antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding clusterin. Further provided are pharmaceutical compositions containing therapeutically or prophylactically effective amounts of the compounds for modulation of clusterin expression and for treatment of animals having diseases or symptoms associated with expression of clusterin.
Inventors:
MONIA BRETT P
FREIER SUSAN M
FREIER SUSAN M
Application Number:
JP2013156811A
Publication Date:
February 13, 2014
Filing Date:
July 29, 2013
Export Citation:
Assignee:
ONCOGENETICS TECHNOLOGIES INC
International Classes:
C12N15/09; C12N15/113; A61K9/107; A61K31/7088; A61K31/712; A61K31/7125; A61K48/00; A61P3/06; A61P9/00; A61P9/10; A61P13/02; A61P13/12; A61P25/00; A61P25/28; A61P35/00; A61P43/00; A61K38/00
Foreign References:
| WO2000049937A2 | 2000-08-31 |
Other References:
JPN5003001229; ＭＩＹＡＫＥ: ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ． Ｖ６, 200005, Ｐ１６５５-１６６３
JPN5003001228; Ｍｏｌ． Ｃｅｌｌｓ， ２０００， Ｖｏｌ．１０， ｐａｇｅｓ １９３-８
JPN5003001230; ＭＩＹＡＫＥ: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ． Ｖ６０, 20000101, Ｐ１７０-１７６
JPN5003001231; ＭＩＹＡＫＥ: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ． Ｖ６０, 20000501, Ｐ２５４７-２５５４
JPN5003001232; ＺＷＡＩＮ: ＥＸＰＥＲＩＭＥＮＴＡＬ ＣＥＬＬ ＲＥＳＥＡＲＣＨ． Ｖ２５７, 200003, Ｐ１０１-１１０
JPN5003001234; Ｃａｎｃｅｒ Ｒｅｓ．， １９９５， Ｖｏｌ．５５， ｐａｇｅｓ ２４３１-７
JPN5003001233; ＵＲＢＩＣＨ: Ｃｉｒｃｕｌａｔｉｏｎ Ｖ１０１, 200002, Ｐ３５２-３５５
JPN5003001228; Ｍｏｌ． Ｃｅｌｌｓ， ２０００， Ｖｏｌ．１０， ｐａｇｅｓ １９３-８
JPN5003001230; ＭＩＹＡＫＥ: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ． Ｖ６０, 20000101, Ｐ１７０-１７６
JPN5003001231; ＭＩＹＡＫＥ: ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ． Ｖ６０, 20000501, Ｐ２５４７-２５５４
JPN5003001232; ＺＷＡＩＮ: ＥＸＰＥＲＩＭＥＮＴＡＬ ＣＥＬＬ ＲＥＳＥＡＲＣＨ． Ｖ２５７, 200003, Ｐ１０１-１１０
JPN5003001234; Ｃａｎｃｅｒ Ｒｅｓ．， １９９５， Ｖｏｌ．５５， ｐａｇｅｓ ２４３１-７
JPN5003001233; ＵＲＢＩＣＨ: Ｃｉｒｃｕｌａｔｉｏｎ Ｖ１０１, 200002, Ｐ３５２-３５５
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Norihiro Fukasawa
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Norihiro Fukasawa