Title:
抗血栓化合物
Document Type and Number:
Japanese Patent JP4705093
Kind Code:
B2
Abstract:
The present invention relates compounds of the formula A oligosaccharide-spacer-GpIIb/IIIa antagonist wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising four to twenty five monosaccharide units, the charge being compensated by positively charged counterions, and wherein the oligosaccharide residue is derived from an oligosaccharide which has (AT-III mediated) anti-Xa activity per se; the spacer is a bond or an essentially pharmacologically inactive linking residue; the GpIIb/IIIa antagonist is a residue mimicking the RGD and/or K(QA)GD fragment of fibrinogen, typically comprising an optionally esterified carboxylate moiety and a basic moiety located within the residue at a distance of 10-20 ANGSTROM from each other; or a pharmaceutically acceptable salt thereof or a prodrug or a solvate thereof. The compounds of the invention have antithrombotic activity and can be used in treating or preventing thrombotic diseases.
Inventors:
Viceman, Rogier Christian
De Colt, Martin
Moulemann, Derek Heritage
Juan Bouker, Constant
De Colt, Martin
Moulemann, Derek Heritage
Juan Bouker, Constant
Application Number:
JP2007501247A
Publication Date:
June 22, 2011
Filing Date:
March 03, 2005
Export Citation:
Assignee:
Sanofui-Aventice
International Classes:
C07K5/072; A61K31/454; A61K31/4545; A61K38/00; A61P7/02; C07H11/00; C07H15/04; C07H15/08; C07K5/00; C07K9/00
Domestic Patent References:
| JP2002501936A | ||||
| JP2001187802A | ||||
| JP2002518407A | ||||
| JP2003520208A | ||||
| JP2000500807A | ||||
| JP11513061A |
Foreign References:
| WO1994015953A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura