Title:
抗腫瘍の漢方薬組成物及びその揮発性油エキス
Document Type and Number:
Japanese Patent JP7026263
Kind Code:
B2
Abstract:
An application of a traditional Chinese medicine composition and a volatile oil extract thereof in preparation of an anti-tumor drug for inhibiting overexpression after mutation of a ras proto-oncogene. The traditional Chinese medicine composition consists of cloves, Villous Amomum Fruit, Chinese Star Anise, Cassia Bark, white pepper, Common Aucklandia Root, and dried ginger. The traditional Chinese medicine composition and the volatile oil extract thereof can significantly inhibit the Caenorhabditis elegans tumor-like multivulva phenotype due to overexpression of the ras proto-oncogene caused by let-60 mutation, so that the multivulva phenotype is transformed into a real vulva wild-type phenotype. The above result indicates that the traditional Chinese medicine composition and the volatile oil extract thereof have the effect of treating a tumor caused by overexpression of the ras gene, and can be used in the preparation of an anti-tumor drug for inhibiting overexpression after mutation of the ras proto-oncogene.
Inventors:
金家▲ファ▼
Ding Reikoto
Somusuke
朱暁萍
Ding Reikoto
Somusuke
朱暁萍
Application Number:
JP2020570032A
Publication Date:
February 25, 2022
Filing Date:
July 10, 2019
Export Citation:
Assignee:
SHANGHAI ZHONGHUA PHARMACEUTICAL CO., LTD
International Classes:
A61K36/9068; A61K31/015; A61K31/085; A61K31/22; A61K31/222; A61K36/285; A61K36/289; A61K36/54; A61K36/61; A61K36/67; A61K36/79; A61K36/9064; A61P35/00
Domestic Patent References:
| JP2000514033A |
Foreign References:
| CN108421017A |
Other References:
實母散 添付文書(株式会社日参製薬保寿堂),2013年08月
三星実母散 添付文書(三星製薬株式会社),2012年11月
上海科学技術出版社,中薬大辞典,第二巻初版第三刷,株式会社小学館,1998年,pp. 834-837, 1134-1139, 1206-1211
薬理と臨床,2009年,Vol. 19, No. 4,pp. 279-305
薬学雑誌,1972年,Vol. 92, No. 3,pp. 328-332
日本東洋醫學會誌,1953年,Vol. 4, No. 2,pp. 23-26
生薬単(ショウヤクタン),改訂第3版第1刷,丸善雄松堂株式会社,2017年,pp. 346-351
三星実母散 添付文書(三星製薬株式会社),2012年11月
上海科学技術出版社,中薬大辞典,第二巻初版第三刷,株式会社小学館,1998年,pp. 834-837, 1134-1139, 1206-1211
薬理と臨床,2009年,Vol. 19, No. 4,pp. 279-305
薬学雑誌,1972年,Vol. 92, No. 3,pp. 328-332
日本東洋醫學會誌,1953年,Vol. 4, No. 2,pp. 23-26
生薬単(ショウヤクタン),改訂第3版第1刷,丸善雄松堂株式会社,2017年,pp. 346-351
Attorney, Agent or Firm:
sk patent corporation
Akihiko Okuno
Hiroyuki Ito
Akihiko Okuno
Hiroyuki Ito