Title:
抗腫瘍剤及び配合剤
Document Type and Number:
Japanese Patent JP7388702
Kind Code:
B2
Abstract:
Provided is: a novel antitumor agent which contains, as an active ingredient, a glutathione concentration-decreasing agent or a glutathione S-transferase inhibitor which is simultaneously administered with an effective amount of an aldehyde dehydrogenase inhibitor; or a novel antitumor agent which contains, as an active ingredient, an aldehyde dehydrogenase inhibitor which is simultaneously administered with an effective amount of a glutathione concentration-decreasing agent or a glutathione S-transferase inhibitor; or a novel compounding agent which contains, as active ingredients, an aldehyde dehydrogenase inhibitor and a glutathione concentration-decreasing agent or glutathione S-transferase inhibitor.
Inventors:
Hideyuki Saya
Osamu Nagano
Shogo Okazaki
Osamu Nagano
Shogo Okazaki
Application Number:
JP2019554284A
Publication Date:
November 29, 2023
Filing Date:
November 15, 2018
Export Citation:
Assignee:
Fujita Gakuen
International Classes:
A61K31/137; A61K31/192; A61K31/403; A61K31/405; A61K31/4402; A61K31/4412; A61K38/06; A61K38/39; A61K39/395; A61P35/00; A61P43/00; C12Q1/02
Domestic Patent References:
| JP2016509045A | ||||
| JP2008517927A |
Foreign References:
| WO2017192740A1 |
Other References:
Hepatology Research,2016年,46,50-57
佐谷秀行他,固形がんのがん幹細胞を標的とした治療戦略の考案,がん分子標的治療,2014年,Vol.12,No.3,p.262-265,264ページ右欄1-37行
DONGHONG J. et al.,Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2009年,Vol.23,p.205-209,Abstract
PARAJULI B. et al.,Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1(ALDH3A1) for the Enhancemen,ChemoBioChem,2014年,Vol.15,No.5,p.701-712,Abstract
佐谷秀行他,固形がんのがん幹細胞を標的とした治療戦略の考案,がん分子標的治療,2014年,Vol.12,No.3,p.262-265,264ページ右欄1-37行
DONGHONG J. et al.,Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast,INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2009年,Vol.23,p.205-209,Abstract
PARAJULI B. et al.,Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1(ALDH3A1) for the Enhancemen,ChemoBioChem,2014年,Vol.15,No.5,p.701-712,Abstract
Attorney, Agent or Firm:
Patent Attorney Corporation Isshiki International Patent Office
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