Title:
抗ウイルス性複素環式化合物
Document Type and Number:
Japanese Patent JP2009526802
Kind Code:
A
Abstract:
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R1-R3 R6c and X1 are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I.
Inventors:
Remoine, Remy
Melville, Chris Richard
Padilla, Fernando
Rothstein, david mark
Vanner, yutta
Melville, Chris Richard
Padilla, Fernando
Rothstein, david mark
Vanner, yutta
Application Number:
JP2008554727A
Publication Date:
July 23, 2009
Filing Date:
February 05, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D487/04; A61K31/407; A61K31/4439; A61K31/4545; A61K31/501; A61K31/506; A61P31/18
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito