ANTIVIRAL PREPARATION

Japanese Patent JP2699050

B2

PURPOSE: To obtain a therapeutically useful preparation containing 2',3'- dideoxy-2',3'-didehydro-2'-fluoronucleoside as an effective component, having the ability to extinguish or reduce the infection for animals with human immunodeficiency virus.
CONSTITUTION: This preparation contains, as the effective component, a compound of the formula [B is purine (except adenine), azapurine, deazapurine, pyrimidine azapyrimidine, deazapyrimidine, or a compound derived from thiazole ring-base; R is H, N3, CN, CHCN, F, Cl, Br, NH2, NHR', NR'2, SR', S(O)R' or S(O)2R' (R' is a 1-3C alkyl, phenyl or tolyl)]. The compound is prepared by selectively protecting 4'-hydroxymethyl group of 2'-deoxy-2'- fluoroarabinonucleoside, then converting 3'-hydroxyl group of the resulted compound into 3'-O-substituent capable of eliminating, further forming a double bond between 2'- and 3'-positions in the five-ring system of the intermediate under the conditions suitable for the elimination reaction, and eliminating the protecting group of 4'-hydroxymethyl group.

JP2023535224	new use
WO/1999/014226	BI- AND TRI-CYCLIC NUCLEOSIDE, NUCLEOTIDE AND OLIGONUCLEOTIDE ANALOGUES

Roman Zet Starkey
Mazamil M Monthly
John sea martin

JP15597893A

January 19, 1998

May 24, 1993

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BRISTOL-MYERS SQUIBB COMPANY

A61K31/7042; A61K31/7052; A61K31/7056; A61K31/70; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P31/12; C07H19/04; C07H19/056; C07H19/06; C07H19/16; C07H19/19; (IPC1-7): A61K31/70; C07H19/06; C07H19/16

JPH01100190A

Takehiko Saito

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