ANTIZYME MODULATOR AND ITS USE

Japanese Patent JP2007176948

A

To provide an agmatine analogue and a polyamine analogue not to be metabolized like agmatine and polyamine.

The analogue is a polyamine analogue of spermine which contains four pieces of amine groups forming four pieces of positive electric charges at a physiological pH, and in which a first amine group and a second amine group, also a third amine group and a fourth amine group are distant from each other by the distance of four pieces of C-C bonds and/or C-N bonds, and the second amine group and the third amine group are distant from each other by the distance of five or more pieces of C-C bonds and/or C-N bonds, and which induces the manifestation of a full-length antizyme.

VERMEULIN NICOLAAS M J
BURNS MARK R
WEBB HEATHER K

JP2007038690A

July 12, 2007

February 19, 2007

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MEDIQUEST THERAPEUTICS INC

C07C211/09; C07D233/24; A61K31/132; A61K31/137; A61K31/155; A61K31/16; A61K31/17; A61K31/18; A61K31/343; A61K31/381; A61K31/4168; A61K31/4178; A61K31/427; A61K31/444; A61K31/454; A61K31/4545; A61K31/473; A61P35/00; A61P43/00; C07C211/14; C07C211/15; C07C211/27; C07C211/29; C07C211/49; C07C211/53; C07C211/54; C07C215/58; C07C217/58; C07C233/13; C07C233/36; C07C233/37; C07C237/10; C07C251/38; C07C275/28; C07C279/00; C07C279/12; C07C279/26; C07C311/05; C07C311/10; C07C311/18; C07C311/29; C07C311/41; C07D211/14; C07D211/26; C07D213/36; C07D219/04; C07D233/16; C07D233/52; C07D295/13; C07D307/91; C07D333/34; C07D401/14; C07D417/04; C40B40/04

JPH0662896A

1994-03-08

US5677350A	1997-10-14
WO1999003823A2	1999-01-28

Hidesaku Yamamoto

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