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Patent Searching and Data


Title:
APO-2 LIGAND/TRAIL VARIANT AND USE THEREOF
Document Type and Number:
Japanese Patent JP2010065037
Kind Code:
A
Abstract:

To provide Apo-2 ligand variant polypeptides.

Apo-2 ligand/TRAIL variant containing one or more amino acid substitutions in a natural sequence of Apo-2 ligand/TRAIL is provided. The Apo-2 ligand/TRAIL variant may contain cysteine substitution. Apo-2 ligand/TRAIL variant polypeptide is included and conjugates with or bind to one or more polyol groups such as a poly(ethylene glycol) 2000 and the like. Nucleic acid molecules encoding such Apo-2 ligand/TRAIL variant, and vectors and host cells containing the nucleic acid molecules encoding the Apo-2 ligand/TRAIL variant are also provided.


Inventors:
Hymowitz, Sarah
Kelley, Robert F.
Lindstrom, Stephanie HO
Application Number:
JP2009000233816
Publication Date:
March 25, 2010
Filing Date:
October 07, 2009
Export Citation:
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Assignee:
GENENTECH INC
International Classes:
C07K14/525; A61K38/00; A61K45/00; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/04; A61P7/06; A61P9/14; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; C07K14/705; C12N15/09; C12N15/19
Foreign References:
WO2001000832A12001-01-04
Attorney, Agent or Firm:
園田 吉隆
小林 義教