Title:
アポトーシス誘導剤及びアポトーシス誘導方法
Document Type and Number:
Japanese Patent JP4462560
Kind Code:
B2
Abstract:
An object of the present invention is to provide a novel means for stably and surely inducing cell apoptosis using the c-myc gene as a target. The present invention relates to an apoptosis-inducing agent containing a protein that interacts with an FBP protein or a polynucleotide encoding the protein as an active ingredient and a method for inducing apoptosis, which comprises a step of causing the apoptosis-inducing agent to come into contact with cells.
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Inventors:
Hideaki Shimada
Kazuyuki Matsushita
Takeshi Tomonaga
Fumio Nomura
Ochiai Takenori
Kazuyuki Matsushita
Takeshi Tomonaga
Fumio Nomura
Ochiai Takenori
Application Number:
JP2005505703A
Publication Date:
May 12, 2010
Filing Date:
March 30, 2004
Export Citation:
Assignee:
National University Corporation Chiba University
International Classes:
A61K38/00; A61K31/7088; A61K35/76; A61K35/761; A61K35/763; A61K38/17; A61K48/00; A61P35/00; A61P43/00; C07K14/47; C12N15/09
Other References:
THOMPSON E.B.,The many roles of c-Myc in apoptosis,Annual Review of Physiology,1998年,Vol.60,p.575-600
LIU, J., et al.,Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum,Cell,2001年 2月 9日,Vol.104, No.3,p.353-363
LIU, J., et al.,The FBP Interacting Repressor Targets TFIIH to Inhibit Activated Transcription,Molecular Cell,2000年 2月,Vol.5, No.2,p.331-341
LIU, J., et al.,Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum,Cell,2001年 2月 9日,Vol.104, No.3,p.353-363
LIU, J., et al.,The FBP Interacting Repressor Targets TFIIH to Inhibit Activated Transcription,Molecular Cell,2000年 2月,Vol.5, No.2,p.331-341
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Nobuko Fukami
Ishii Teiji
Satoshi Fujita
Nobuko Fukami