Title:
ウシ泌乳関連向免疫性タンパク質(CD14)、コード遺伝子、およびB細胞活性化における適用
Document Type and Number:
Japanese Patent JP4447058
Kind Code:
B2
Abstract:
A protein purified from bovine colostral whey and isolated nucleotide sequences encoding the protein is identified. The isolated bovine protein is termed Bovine Lactation Associated Immunotropic (Bo-LAIT) protein. The human homologue of Bo-LAIT protein, Hu-LAIT protein, is also described. A method of activating B cells, and particularly of activating B cells in a mammal, such as a human, in need of such activation by administering LAIT protein is described. LAIT protein can be incorporated into infant formula. LAIT protein can be administered to an infant, as by feeding to the infant such formula. LAIT protein can incorporated as part of a vaccination. LAIT protein can administered to a patient having a T cell immune deficiency, for example, a particular T cell dysfunction in which gp39 (CD40L) is under expressed an or totally absent from the cell surface of patient T cells. Preparation of medicaments including LAIT protein for activating B cells in a mammal in need of such activation is described. Natural or recombinant LAIT protein can be used.
Inventors:
Julius, Michael, H.
Philip, Dominique.
Alizabeth Kiabi, Camel.
Philip, Dominique.
Alizabeth Kiabi, Camel.
Application Number:
JP52303698A
Publication Date:
April 07, 2010
Filing Date:
November 18, 1997
Export Citation:
Assignee:
The Wellesley Hospital Foundation
International Classes:
C12N15/09; A61K38/00; A61K39/39; A61P37/04; A61P43/00; C07K14/705; C07K14/715; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; G01N33/68
Other References:
Proc. Natl. Acad. Sci. USA, 1996年, Vol.93, p.5156-5160
Database DDBJ/EMBL/GenBank [online], 1996年 9月12日, Accessin No. U48356, URL, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=1532130
J. Immunol., 1994年, Vol.153, p.972-978
Database DDBJ/EMBL/GenBank [online], 1996年 9月12日, Accessin No. U48356, URL, http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=1532130
J. Immunol., 1994年, Vol.153, p.972-978
Attorney, Agent or Firm:
Tamura Tadashi
Yoshikazu Tani
Kazuo Abe
Yoshikazu Tani
Kazuo Abe