Title:
核酸における選択された鎖間架橋を用いた適用およびその作製方法
Document Type and Number:
Japanese Patent JP4838937
Kind Code:
B2
Abstract:
The invention provides methods and means for generating interstrand cross-links in nucleic acid at certain specific locations in said nucleic acid. Said certain specific locations in said nucleic acid can be selected from other locations through hybridising nucleic acid present in said selected location with complementary nucleic. In one aspect the invention provides a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links comprising hybridising at least one selected single strand sequence with a complementary single strand nucleic acid wherein said selected sequence or said complementary nucleic acid or both comprise a cross-linking agent. The means and methods of the invention may be used in and beneficial for a wide variety of applications, such as the generation of nucleic acid probes and the treatment of diseases such as cancer.
Inventors:
Volkers, Hermann
Gote Bray, Robert Yohem
Houthof, Hendrick Yang
Van Haleswijk, Robertus Petrus Maria
Tanke, Hendricks Johannes
Larp, Anton Krass
Gote Bray, Robert Yohem
Houthof, Hendrick Yang
Van Haleswijk, Robertus Petrus Maria
Tanke, Hendricks Johannes
Larp, Anton Krass
Application Number:
JP2000585445A
Publication Date:
December 14, 2011
Filing Date:
December 03, 1999
Export Citation:
Assignee:
Kreatech Biotechnology B.V.
International Classes:
C12N15/09; G01N33/50; C07K1/13; C12Q1/68; C12Q1/6816; C12Q1/6832; C12Q1/6841; C12Q1/686; G01N33/53; G01N33/566; G01N33/58
Foreign References:
| WO1998045304A1 | 1998-10-15 | |||
| FR2755146A1 | 1998-04-30 |
Attorney, Agent or Firm:
Keiichiro Saikyo