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Title:
AQUEOUS COMPOSITION
Document Type and Number:
Japanese Patent JP2014111661
Kind Code:
A
Abstract:

To provide an aqueous composition for topical administration using a 15-keto-prostaglandin compound as an active ingredient, extremely useful for ophthalmology.

Disclosed is an aqueous composition which comprises a 15-keto-prostaglandin compound as an active ingredient and contains a polyoxyethylene castor oil derivative. The solubility of the 15-keto-PG compound in water can be improved by the addition of the polyoxyethylene castor oil derivative. The aqueous composition preferably further contains a quaternary ammonium-type cationic surfactant as a preservative. The composition shows a potent antibacterial effect on the contamination of normal flora occurring in eyes such as Staphylococcus aureus and is useful as an ophthalmic composition such as an eye drop.


Inventors:
HIRATA TAKASHI
HARADA YASUHIRO
UENO TAKASHI
Application Number:
JP2014050564A
Publication Date:
June 19, 2014
Filing Date:
March 13, 2014
Export Citation:
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Assignee:
R TECH UENO KK
SUCAMPO AG
International Classes:
A61K31/5575; A61K9/08; A61K47/34; A61P27/02; A61P27/06
Domestic Patent References:
JPH11500122A1999-01-06
JP2001515502A2001-09-18
JP2002520368A2002-07-09
JP2002234851A2002-08-23
JP2008189567A2008-08-21
Foreign References:
WO2005018646A12005-03-03
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Sakurai Yoko



 
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