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Title:
AQUEOUS REAGENT AND CATALYTIC PROCESS USEFUL FOR CLEAVING PROTECTED FUNCTIONAL GROUP
Document Type and Number:
Japanese Patent JPH08325167
Kind Code:
A
Abstract:

To obtain a reagent having an alkoxyl group having an unsaturated group at the β-position, e.g. propargyl, benzyl or allyl group and useful for cleaving an unsaturated alkoyloxycarbonyl functional group.

(A) A reagent comprising (I) an aqueous phase, (ii) a catalyst containing at least one group VIII element of the periodic table of elements, capable of forming a complex with a water-soluble coordinating agent and held in the aqueous phase and (iii) a nucleophilic compound having water solubility is reacted with (B) a starting material having a the β-position protected with an unsaturated alkoyloxycarbonyl group and further a substituent group containing >5C in the alkoyloxycarbonyl group and a substituent group containing >5 carbon atoms grafted onto the alkoyloxycarbonyl group to cleave the protecting functional group. Furthermore, the component A is preferably a multiphase system, preferably a two-phase system such as the nucleophilic compound is soft and the water-soluble coordinating agent is a phosphine, etc., enhancing the basicity, the nucleophilic compound has a highly hydrophilic functional group in the molecule, etc.


Inventors:
JIYANNMARII BERUNAARU
EROORU BURAARU
JIYANNPIEERU JIYUNE
MONIKU SABINIYAKU
Application Number:
JP1996000109901
Publication Date:
December 10, 1996
Filing Date:
April 30, 1996
Export Citation:
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Assignee:
RHONE POULENC CHIMIE
International Classes:
B01J31/28; B01J31/18; B01J31/24; C01B21/16; C07B41/02; C07B41/08; C07B43/04; C07B51/00; C07B61/00; C07C27/02; C07C29/09; C07C29/147; C07C33/02; C07C33/025; C07C33/14; C07C33/22; C07C35/12; C07C41/26; C07C51/09; C07C57/32; C07C67/31; C07C209/62; C07C211/27; C07C211/52; C07C213/02; C07C215/30; C07C227/18; C07C227/20; C07C229/36; C07C241/02; C07C245/14; C07D207/16; C07D209/12; C07D211/62; C07D295/023; C07D295/20; C07D501/04; C07F7/18; C07F15/00; C07H1/00; C07H9/04; C07H13/12; C07H15/18; C07H19/01; C07K1/00; C07K1/02; C07K1/06; C07K1/113; C07K1/12; C07K5/08; C09K3/00; C07D; (IPC1-7): C07B51/00; B01J31/28; C01B21/16; C07B41/02; C07B41/08; C07B43/04; C07C27/02; C07C209/62; C07C211/27; C07C211/52; C07C213/02; C07C215/30; C07C227/18; C07C229/36; C07D207/16; C07D209/12; C07D211/62; C07D295/20; C07D501/04; C07H1/00; C07H13/12; C07K1/02; C07K5/08
Attorney, Agent or Firm:
石田 敬 (外3名)