Title:
ARGINASE INHIBITORS AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2019052161
Kind Code:
A
Abstract:
To provide arginase enzyme inhibitors for treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal.SOLUTION: An inhibitor comprises a composition comprising an alpha-amino acid compound, or a derivative thereof, or a salt thereof, wherein a first substituent and a second substituent are linked to the alpha-carbon of the compound. The first substituent comprises a moiety selected from the group consisting of a boronic acid and N-hydroxy guanidine. The second substituent comprises a proximal nitrogen atom, wherein: the proximal nitrogen is basic; and the proximal nitrogen is separated from the alpha-carbon by a chain of two, three or four carbons, with the proviso that the compound is not 2-amino-6-borono-2-(3-(piperazin-1-yl)propyl)hexanoic acid, 2-(3-(4-acetylpiperazin- 1-yl)propyl)-2-amino-6-boronohexanoic acid, and the like.SELECTED DRAWING: Figure 4
Inventors:
BRUCE EDWARD TOMCZUK
GARY LEE OLSON
RICHARD SCOTT POTTORF
WANG JANE
BHASKARA RAO NALLAGANCHU
GARY LEE OLSON
RICHARD SCOTT POTTORF
WANG JANE
BHASKARA RAO NALLAGANCHU
Application Number:
JP2018220616A
Publication Date:
April 04, 2019
Filing Date:
November 26, 2018
Export Citation:
Assignee:
ASTRAZENECA UK LTD
International Classes:
A61K31/69; A61K45/00; A61K49/00; A61K49/04; A61K49/10; A61K51/04; A61P7/00; A61P7/02; A61P7/08; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P15/06; A61P15/10; A61P17/02; A61P17/06; A61P19/02; A61P21/02; A61P25/00; A61P29/00; A61P31/00; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07F5/02
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto