Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ARGINASE INHIBITORS AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2019052161
Kind Code:
A
Abstract:
To provide arginase enzyme inhibitors for treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal.SOLUTION: An inhibitor comprises a composition comprising an alpha-amino acid compound, or a derivative thereof, or a salt thereof, wherein a first substituent and a second substituent are linked to the alpha-carbon of the compound. The first substituent comprises a moiety selected from the group consisting of a boronic acid and N-hydroxy guanidine. The second substituent comprises a proximal nitrogen atom, wherein: the proximal nitrogen is basic; and the proximal nitrogen is separated from the alpha-carbon by a chain of two, three or four carbons, with the proviso that the compound is not 2-amino-6-borono-2-(3-(piperazin-1-yl)propyl)hexanoic acid, 2-(3-(4-acetylpiperazin- 1-yl)propyl)-2-amino-6-boronohexanoic acid, and the like.SELECTED DRAWING: Figure 4

Inventors:
BRUCE EDWARD TOMCZUK
GARY LEE OLSON
RICHARD SCOTT POTTORF
WANG JANE
BHASKARA RAO NALLAGANCHU
Application Number:
JP2018220616A
Publication Date:
April 04, 2019
Filing Date:
November 26, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ASTRAZENECA UK LTD
International Classes:
A61K31/69; A61K45/00; A61K49/00; A61K49/04; A61K49/10; A61K51/04; A61P7/00; A61P7/02; A61P7/08; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P15/06; A61P15/10; A61P17/02; A61P17/06; A61P19/02; A61P21/02; A61P25/00; A61P29/00; A61P31/00; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07F5/02
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto