Title:
AROMATASE INHIBITORY STEROID DERIVATIVE
Document Type and Number:
Japanese Patent JPS62155295
Kind Code:
A
Abstract:
NEW MATERIAL:19-Azido-4-androstene-3,17-dione expressed by formula I.
USE: Useful for treating estrogen-dependent tumor, e.g. mammary cancer, uterine cancer, etc., as an estrogen biosynthesis inhibitor.
PREPARATION: For example, 19-hydroxy-4-androstene-3,17-dione expressed by formula II is reacted with a sulfonylating agent, e.g. trifluoromethanesulfonic acid anhydride, etc., in a solvent, e.g pyridine, etc., as necessary, in the presence of a base to give a compound expressed by formula III, which is then reacted with sodium azide in a large excess in a solvent, e.g. DMF, etc., while heating for some ten hours.
Inventors:
TERASAWA TADAO
OKADA TOSHIHIKO
SUZUKI TETSURO
KANDA MEGUMI
OKADA TOSHIHIKO
SUZUKI TETSURO
KANDA MEGUMI
Application Number:
JP29856485A
Publication Date:
July 10, 1987
Filing Date:
December 27, 1985
Export Citation:
Assignee:
SHIONOGI & CO
International Classes:
C07J41/00; A61K31/565; A61P35/00; (IPC1-7): A61K31/565; C07J41/00
Other References:
J.CHEM.SOC.CHEM.COMMUN=1985
Attorney, Agent or Firm:
Mitsutaka Iwasaki