Title:
芳香族アミド誘導体、それを含有する医薬組成物およびそれらの医薬用途
Document Type and Number:
Japanese Patent JP4943858
Kind Code:
B2
Abstract:
A present invention provides aromatic amide derivatives which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like, and are represented by the general formula (I):
wherein R 1 represents a hydrogen atom or a C 1-6 alkyl group which may have a substituent, R 2 is a hydrogen atom or a C 1-6 alkyl group, R 3 is a hydrogen atom, a C 1-6 alkyl group or the like, R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, R 7 is a hydrogen atom, a heteroaryl group which may have a substituent, a C 3-8 cycloalkyl group', an amino group which may have a substituent or a C 1-6 alkoxy group which may have a substituted group;
M 1 is a single bond, a C 1-4 alkylene group or the like
Y is N or CR F (in the formula, R F represents a hydrogen atom, a C 1-6 alkyl group or the like
or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or pharmaceutical compositions comprising the same and pharmaceutical uses thereof.
Inventors:
Kenji Yokoyama
Suzuki Ritsu
Kondo Ryudai
Atsushi Kondo
Hiroaki Kobayashi
Suzuki Ritsu
Kondo Ryudai
Atsushi Kondo
Hiroaki Kobayashi
Application Number:
JP2006545073A
Publication Date:
May 30, 2012
Filing Date:
November 15, 2005
Export Citation:
Assignee:
Kissei Pharmaceutical Co., Ltd.
International Classes:
C07D243/14; A61K31/5513; A61P7/04; A61P13/02; A61P43/00; C07D401/06; C07D401/14; C07D403/06; C07D403/10; C07D405/06; C07D407/04; C07D409/06; C07D413/06; C07D413/14; C07D417/06
Domestic Patent References:
| JP2004501899A | ||||
| JP2003519228A | ||||
| JP6016643A |
Foreign References:
| WO1995034540A1 |