Title:
動静脈及び静脈の移殖治療:方法及び組成物
Document Type and Number:
Japanese Patent JP3958362
Kind Code:
B2
Abstract:
A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes. Preferably, oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.
Inventors:
The Lessky, Andrew
Shii
Shii
Application Number:
JP53188996A
Publication Date:
August 15, 2007
Filing Date:
April 19, 1996
Export Citation:
Assignee:
Thomas Jefferson University
International Classes:
A61K48/00; A61K31/70; C12N15/09; A61K31/7088; A61K31/715; A61L27/00; A61P9/00; A61P9/14; A61P11/00; A61P17/00; A61P29/00; A61P35/00; A61P43/00; C07H21/00; C07H21/04; C12N5/10; C12N5/22; C12N15/113; A61K38/00
Foreign References:
| WO1994015646A1 | ||||
| WO1993001286A1 | ||||
| WO1993008845A1 |
Attorney, Agent or Firm:
Takashi Ishida
Yoshio Yoshio
Toshio Toda
Masaya Nishiyama
Yoshio Yoshio
Toshio Toda
Masaya Nishiyama