Title:
人工組織灌流デバイス、人工組織を用いた薬剤評価方法
Document Type and Number:
Japanese Patent JP7280618
Kind Code:
B2
Abstract:
An object of the present invention is to provide an artificial tissue perfusion device capable of analyzing the interaction between a vascular cell layer and a parenchymal cell layer with high accuracy. An artificial tissue perfusion device includes a co-culture system (C) in which a plurality of types of cell are cultured. The co-culture system has a tubular well part (10) having a culture space (11) inside; a base material (20) having a perfusion flow path (26) which extends in a predetermined direction and is perfused with a medium, and a holding part (23) which opens to the perfusion flow path and holds the well part attachably and detachably; and a gel membrane (30) having a form of a porous membrane and disposed at an end portion of the well part facing the perfusion flow path in a case where the well part is held by the holding part. A tissue-based cell is cultured on a surface side of the gel membrane facing the culture space, and a luminal cell is cultured on a surface side of the gel membrane facing the perfusion flow path.
Inventors:
Masaharu Takeuchi
Yuya Morimoto
Shogo Nagata
Yuya Morimoto
Shogo Nagata
Application Number:
JP2019562508A
Publication Date:
May 24, 2023
Filing Date:
December 28, 2018
Export Citation:
Assignee:
National University Corporation The University of Tokyo
International Classes:
C12M1/00; C12M3/00; C12Q1/02
Foreign References:
| WO2017091718A1 | ||||
| EP2639293A1 | ||||
| WO2017126532A1 | ||||
| WO2016069892A1 |
Other References:
BUNSEKI KAGAKU,2016年,Vol.65,p.241-247
Attorney, Agent or Firm:
Sumio Tanai
Masato Iida
Onami Kazunori
Masato Iida
Onami Kazunori