ARYL-QUINAZOLINE/ARYL-2-AMINO-PHENYL METHANONE DERIVATIVES WHICH PROMOTE RELEASE OF PARATHYROID HORMONE

Title:

ARYL-QUINAZOLINE/ARYL-2-AMINO-PHENYL METHANONE DERIVATIVES WHICH PROMOTE RELEASE OF PARATHYROID HORMONE

Document Type and Number:

Japanese Patent JP2010159258

Kind Code:

A

Abstract:

To provide a pharmaceutical composition containing a compound having activity as a PTH release promoter.

The pharmaceutical composition for preventing-treating seizures, stroke, hypoxia-induced nerve cell damage, epilepsy, neurodegenerative diseases, Alzheimer's disease, Huntington's disease, Parkinson's disease, dementia, depression, anxiety, panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, congestive heart failure, hypertension; gut motility disorders, diarrhoea, burns, ulcerations, wounds, osteoporosis, fractures, osteopathy, osteomalacia, periodontal bone loss, bone loss due to arthritis, hypoparathyroidism or the like includes a novel 4-aryl-2(1H)-quinazolinone derivative or aryl-(2-amino-phenyl)-methanone derivative which promote the PTH release, for example, 1-(2,3-dimethoxy-quinoxalin-6-ylmethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazoline-2-one in admixture with a pharmaceutically acceptable excipient, diluent or carrier.

Inventors:

ALTMANN EVA
BEERLI RENE
GERSPACHER MARC
RENAUD JOHANNE
WEILER SVEN
WIDLER LEO

Application Number:

JP2010012104A

Publication Date:

July 22, 2010

Filing Date:

January 22, 2010

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

A61K31/517; A61P1/00; A61P1/02; A61P1/12; A61P5/14; A61P5/18; A61P9/10; A61P9/12; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/20; A61P25/22; A61P25/24; A61P25/28; C07C17/12; C07C45/30; C07C205/37; C07C205/44; C07C205/45; C07C225/22; C07C229/18; C07C255/24; C07C255/25; C07C317/18; C07C317/32; C07C323/25; C07D213/64; C07D239/78; C07D239/82; C07D239/93; C07D317/58; C07D401/06; C07D401/12; C07D403/06; C07D403/10; C07D405/06; C07D409/06; C07D413/06; C07D417/06

Attorney, Agent or Firm:

Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Yasushi Ochiai

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