Title:
Aryl dihydropillage non, piperidinone as MGAT2 inhibitor
Document Type and Number:
Japanese Patent JP6078601
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I):
or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
Inventors:
Huj turdi
John Jay Hangerland
Earl Michael Lawrence
Dong Chen
Saleem Ahmad
Way men
Robert Paul Brigans
Pratic de Bastail
Guohua Jao
John Jay Hangerland
Earl Michael Lawrence
Dong Chen
Saleem Ahmad
Way men
Robert Paul Brigans
Pratic de Bastail
Guohua Jao
Application Number:
JP2015174123A
Publication Date:
February 08, 2017
Filing Date:
September 03, 2015
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/4439; A61K31/4418; A61K31/444; A61K31/497; A61K31/501; A61K31/506; A61K31/662; A61K45/00; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P17/02; A61P25/00; A61P27/02; A61P27/06
Foreign References:
| WO2008038768A1 | ||||
| WO2010095767A1 | ||||
| US3073838 |
Other References:
永井 八,p-置換アセトフェノンのCope-Knoevenagel反応で生成する二次縮合物の構造,日本化学雜誌,1968年,89(8),pp. 819-820
SAKURAI, A. et al.,The Cyclization of Ethyl Cyanoacetate and Ketones by Ammonium Acetate,Bulletin of the Chemical Society of Japan,1967年,40(7),pp. 1680-1684
MCELVAIN, S. M. et al.,Piperidine Derivatives. XXX. 1,4-Dialkyl-4-arylpiperidines,Journal of the American Chemical Society,1958年,80(15),pp. 3915-3923
CARRIE ROBERT,SUR LA CONDENSATION DE LA BENZALACETOPHENONE 以下省略,COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L'ACADEMIE DES SCIENCES,1963年,V257 N18,P2849-2851
SAKURAI, A. et al.,The Cyclization of Ethyl Cyanoacetate and Ketones by Ammonium Acetate,Bulletin of the Chemical Society of Japan,1967年,40(7),pp. 1680-1684
MCELVAIN, S. M. et al.,Piperidine Derivatives. XXX. 1,4-Dialkyl-4-arylpiperidines,Journal of the American Chemical Society,1958年,80(15),pp. 3915-3923
CARRIE ROBERT,SUR LA CONDENSATION DE LA BENZALACETOPHENONE 以下省略,COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L'ACADEMIE DES SCIENCES,1963年,V257 N18,P2849-2851
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Mizuhara Masahiro
Nagatoshi Shinagawa
Mizuhara Masahiro