Title:
アリール置換脂環式化合物及びそれを含有する医薬組成物
Document Type and Number:
Japanese Patent JP4250423
Kind Code:
B2
Abstract:
An aryl-substituted alicyclic compound of the formula (I): wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is -CONH-, etc., R<3> is hydrogen, etc., R<5> is hydrogen, aryl, etc., R<6> is a mono-substituted amino (e,g., benzyloxycarbonylamino), R<7> is hydrogen, etc., and a process for preparation thereof, and a pharmaceutical composition containing the same. The compound of the present invention has a high selectivity for alpha v beta 3 integrin, and exhibits a potent inhibitory activity thereto, and hence, it is useful as a preventive or/and a therapeutic agent for a disease in which alpha v beta 3 integrin is involved.
Inventors:
Moriya Toshiya
Seiji Iwama
Notake Mitsue
Tomoko Kitano
Seiji Iwama
Notake Mitsue
Tomoko Kitano
Application Number:
JP2002573752A
Publication Date:
April 08, 2009
Filing Date:
March 14, 2002
Export Citation:
Assignee:
Sumitomo Dainippon Pharma Co., Ltd.
International Classes:
C07D211/62; A61K31/445; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61K31/506; A61K31/551; A61P9/00; A61P9/10; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P35/04; A61P37/00; A61P43/00; C07D233/50; C07D239/14; C07D239/16; C07D239/42; C07D243/04; C07D295/185; C07D401/04; C07D401/12; C07D401/14; C07D413/14
Domestic Patent References:
| JP7503944A |
Foreign References:
| WO1999052872A1 | ||||
| WO2000006169A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Nagatoshi Shinagawa
Nagatoshi Shinagawa