Title:
アリールスルホンアミド
Document Type and Number:
Japanese Patent JP4611962
Kind Code:
B2
Abstract:
Compounds of formula (I)
(in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
Inventors:
Angashe, Solomon
Way,chen
Wright, Jay Jay
Andrew Pennell
Way,chen
Wright, Jay Jay
Andrew Pennell
Application Number:
JP2006311085A
Publication Date:
January 12, 2011
Filing Date:
November 17, 2006
Export Citation:
Assignee:
Chemocentrix, Incorporated
International Classes:
C07D213/89; A61K31/4425; A61K31/4439; A61K31/4725; A61P1/04; A61P11/00; A61P17/00; A61P17/06; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D213/26; C07D213/50; C07D213/70; C07D213/74; C07D213/84; C07D217/24; C07D241/12; C07D413/12
Domestic Patent References:
| JP2005526857A | ||||
| JP2002512957A |
Foreign References:
| WO2002030358A1 |
Other References:
R. SILVESTRI,MEDICINAL CHEMISTRY RESEARCH,米国,BIRKHAUSER, BOSTON,2002年,V11 N4,P195-218
Arch. Pharm.(Weinheim),1981年,Vol.314, No.81,p.852-861
Arch. Pharm.(Weinheim),1980年,Vol.313, No.80,p.27-34
Arch. Pharm.(Weinheim),1979年,Vol.319, No.79,p.254-261
Org. Lett.,2002年 4月,Vol.4, No.1,p.139-141
European Journal of Medicinal Chemistry,2002年 2月,Vol. 37, No. 2,p.147-161
Arch. Pharm.(Weinheim),1981年,Vol.314, No.81,p.852-861
Arch. Pharm.(Weinheim),1980年,Vol.313, No.80,p.27-34
Arch. Pharm.(Weinheim),1979年,Vol.319, No.79,p.254-261
Org. Lett.,2002年 4月,Vol.4, No.1,p.139-141
European Journal of Medicinal Chemistry,2002年 2月,Vol. 37, No. 2,p.147-161
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hirose Shinobu