Title:
ASPARTATE-β-HYDROXYLASE INDUCES EPITOPE-SPECIFIC T CELL RESPONSES IN TUMORS
Document Type and Number:
Japanese Patent JP2020125325
Kind Code:
A
Abstract:
To provide a peptide-based immunotherapy for ASPH-expressing tumors.SOLUTION: A composition comprising a therapeutically effective amount of a purified aspartate-β-hydroxylase (ASPH) peptide, wherein the peptide comprises at least 7 amino acids in length and fewer amino acids than the full length ASPH protein and wherein the peptide comprises an HLA class I or class II-restricted epitope sequence.SELECTED DRAWING: Figure 6
Inventors:
WANDS JACK R
Application Number:
JP2020073221A
Publication Date:
August 20, 2020
Filing Date:
April 16, 2020
Export Citation:
Assignee:
RHODE ISLAND HOSPITAL
International Classes:
A61K39/00; A61K39/39; A61P35/00; C07K19/00; C12N5/10
Domestic Patent References:
| JP2013500261A | 2013-01-07 | |||
| JP2008527001A | 2008-07-24 |
Foreign References:
| WO2013106834A2 | 2013-07-18 | |||
| WO2014010231A1 | 2014-01-16 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto