Title:
弱毒化グラム陰性菌
Document Type and Number:
Japanese Patent JP4338528
Kind Code:
B2
Abstract:
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.
Inventors:
Krug Helen Rachel
Shah Jacqueline Elizabeth
Feldman Robert Graham
Kutebroze Sylvain Gabriel
Le Gros Francois-Xavier
Shah Jacqueline Elizabeth
Feldman Robert Graham
Kutebroze Sylvain Gabriel
Le Gros Francois-Xavier
Application Number:
JP2003583304A
Publication Date:
October 07, 2009
Filing Date:
April 04, 2003
Export Citation:
Assignee:
Merial LLC
International Classes:
C12N15/09; G01N33/569; A61K39/102; A61K39/39; A61K39/395; A61P31/04; C07K14/285; C12N1/21; A61K39/00
Foreign References:
| WO2000061724A1 |
Other References:
PNAS,Vol.98,No.6(2001)p.3460-3465
J.Clin.Microbiol.,Vol.39,No.3(2001)p.924-929
Microb.Pathog.,Vol.29(2000)p.25-38
JBC,Vol.273,No.14(1998)p.8454-8458
J.Clin.Microbiol.,Vol.39,No.3(2001)p.924-929
Microb.Pathog.,Vol.29(2000)p.25-38
JBC,Vol.273,No.14(1998)p.8454-8458
Attorney, Agent or Firm:
Masaki Hirota
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