Title:
固相合成における自動アリル脱保護
Document Type and Number:
Japanese Patent JP3600268
Kind Code:
B2
Abstract:
A method for removing an allyl protecting group from an allyl-protected derivative of a biologically relevant amino acid is disclosed. One relevant aspect of the method is the use of soluble organometallic catalyst, such as an organopalladium catalyst. Preferably, soluble tetrakistriphenylphosphine palladium (0) is used. The allyl deprotection method now disclosed is suitable for use on an instrument for automated peptide synthesis. Methods of preparing the soluble organometallic catalyst are also disclosed, as are soluble catalyst compositions.
Inventors:
Fernando Albericio
Stephen A. Kates
Stephen A. Kates
Application Number:
JP8917894A
Publication Date:
December 15, 2004
Filing Date:
April 05, 1994
Export Citation:
Assignee:
Perceptive Biosystems Incorporated
International Classes:
B01J19/00; B01J23/44; B01J31/24; B01J31/28; C07B61/00; C07K1/06; C07K1/113; C07K1/12; C40B40/10; C40B60/14; (IPC1-7): C07K1/06; B01J23/44; B01J31/24
Attorney, Agent or Firm:
Motohiro Kurauchi
Hiroshi Kazama
Hiroshi Kazama