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Title:
AX-2, ITS PREPARATION AND ANTITUMOR AGENT CONTAINING AX-2
Document Type and Number:
Japanese Patent JPS5978190
Kind Code:
A
Abstract:

NEW MATERIAL:AX-2 of formula having the following physical and chemical properties: melting point, 75.5W77.5°C; elemental analysis, C 55.16%, H 5.55%, N 11.74%; specific rotation, [α]D=-27.3° (C=0.17, CHCl3); solubility, soluble in ethyl acetate, chloroform, methanol, etc., hardly soluble in water, insoluble in petroleum ether and n-hexane.

USE: An antitumor agent.

PROCESS: A microbial strain belonging to Streptomyces genus or Micromonospora genus and capable of producing AX-2 [e.g. Streptomyces caespitosus T-17-135 (NRRL 12508)] is cultured in a medium under aerobic condition to produce and accumulate the AX-2 in the cultured product. The filtrate of the product is adsorbed with a synthetic adsorbent etc., and eluted e.g. with methanol. The solvent is removed from the eluate, and the residue is purified to obtain AX-2.


Inventors:
ISHII SHINZOU
KATSUMATA SHIGEO
ARAI TAKEMITSU
ASHIZAWA TADASHI
MORIMOTO MAKOTO
SHIRAHATA KIMIKATSU
SAITOU YUTAKA
KOUNO KAZUMICHI
Application Number:
JP1982000189467
Publication Date:
May 04, 1984
Filing Date:
October 28, 1982
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
A61K31/47; A61P35/00; A61P35/02; C07D471/16; C12P17/18; C12R1/465; (IPC1-7): A61K31/47; C07D471/16



 
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