Title:
AZAADAMANTANE ESTER AND CARBAMATE DERIVATIVES, AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2014205695
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds that interact selectively with α7-containing neuronal nicotinic receptors (NNRs), α4β2 NNRs, or both α7 and α4β2 NNRs to effectively treat mild cognitive impairment, age-associated memory impairment (AAMI), senile dementia, AIDS dementia, Pick's disease, dementia associated with Lewy bodies, dementia associated with Down's syndrome, amyotrophic lateral sclerosis, Huntington's disease, smoking cessation, schizoaffective disorder, bipolar and manic disorders, diminished CNS function associated with traumatic brain injury, acute pain, post-surgical pain, chronic pain, inflammatory pain, and the like.SOLUTION: This invention relates to a compound that is a substituted azaadamantane ester and carbamate derivative shown in formula (I), or a pharmaceutically acceptable salt, amide, or a prodrug.
Inventors:
MICHAEL R SCHRIMPF
NERSESIAN DIANA L
SIPPY KEVIN B
JI JIANGUO
LI TAO
SHI LEI
NERSESIAN DIANA L
SIPPY KEVIN B
JI JIANGUO
LI TAO
SHI LEI
Application Number:
JP2014124038A
Publication Date:
October 30, 2014
Filing Date:
June 17, 2014
Export Citation:
Assignee:
ABBVIE INC
International Classes:
C07D471/18; A61K31/439; A61K45/00; A61P21/02; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/34; A61P29/00; A61P31/18; A61P43/00
Domestic Patent References:
| JPH04225979A | 1992-08-14 | |||
| JPH02288880A | 1990-11-28 | |||
| JP2002030084A | 2002-01-29 | |||
| JPWO2008096870A1 | 2010-05-27 | |||
| JPS6341429A | 1988-02-22 |
Foreign References:
| WO1995021820A1 | 1995-08-17 | |||
| CH675072A5 | 1990-08-31 |
Attorney, Agent or Firm:
In the patent business corporation Kawaguchi 國 case, it is a patent firm.