Title:
AZACYCLOALKYL-SUBSTITUTED ACETIC ACID DERIVATIVE FOR USE AS MMP INHIBITOR
Document Type and Number:
Japanese Patent JP2009137997
Kind Code:
A
Abstract:
To provide a method for inhibiting matrix degrading metalloproteinase and provide a preventive treatment for the matrix metalloproteinase dependent conditions in mammals.
The compounds of formula (I) (wherein R represents OH or NHOH; R1 represents hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, or the like; R2 represents biarylsulfonyl, or the like; R3 represents hydrogen, optionally substituted lower alkyl, or the like; R4 and R5 each represents hydrogen, lower alkyl, lower alkoxycarbonyl, or the like; m is 0, 1, 2, or 3); pharmaceutically acceptable prodrug derivatives thereof; phamaceutically acceptable salts thereof; and use of phamaceutical compositions comprising its salt are provided.
Inventors:
FUJIMOTO ROGER AKI
MCQUIRE LESLIE WIGHTON
MONOVICH LAUREN G
NANTERMET PHILIPPE
PARKER DAVID THOMAS
ROBINSON LESLIE ANN
SKILES JERRY W
TOMMASI RUBEN ALBERTO
MCQUIRE LESLIE WIGHTON
MONOVICH LAUREN G
NANTERMET PHILIPPE
PARKER DAVID THOMAS
ROBINSON LESLIE ANN
SKILES JERRY W
TOMMASI RUBEN ALBERTO
Application Number:
JP2009014415A
Publication Date:
June 25, 2009
Filing Date:
January 26, 2009
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D211/34; C12N9/99; A61K31/40; A61K31/445; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4725; A61K31/496; A61K31/501; A61K31/5377; A61K31/55; A61P1/02; A61P1/04; A61P7/00; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P19/10; A61P25/00; A61P25/02; A61P25/14; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P35/04; A61P43/00; C07D211/32; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/14; C07D417/04; C07D417/12; C07D417/14
Domestic Patent References:
| JPH11116549A | 1999-04-27 | |||
| JPH11505502A | 1999-05-21 | |||
| JP4292321B2 | 2009-07-08 |
Foreign References:
| WO2001070691A1 | 2001-09-27 | |||
| WO2001070690A1 | 2001-09-27 | |||
| WO1998050348A1 | 1998-11-12 | |||
| WO1999007675A1 | 1999-02-18 | |||
| WO1999006340A2 | 1999-02-11 | |||
| WO1997027174A1 | 1997-07-31 | |||
| US5817822A | 1998-10-06 |
Other References:
JPN6008047842; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４４， Ｎｏ．１６, 200108, ｐ．２４９９-２５０２
JPN6008047841; Ａｎａｌｙｔｉｃａｌ ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７３， Ｎｏ．３, 200102, ｐ．７０８-７１４
JPN6008047841; Ａｎａｌｙｔｉｃａｌ ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７３， Ｎｏ．３, 200102, ｐ．７０８-７１４
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Previous Patent: MEDICINAL COMPOSITION CONTAINING MYCOPHENOLIC ACID OR SALT OF MYCOPHENOLATE
Next Patent: NEMATICIDAL COMPOSITION
Next Patent: NEMATICIDAL COMPOSITION