Title:
アゼチジン誘導体及びそのプロドラッグ
Document Type and Number:
Japanese Patent JP7312745
Kind Code:
B2
Abstract:
An object of the present invention is to provide a compound useful as a therapeutic or prophylactic drug for a disease involving the immune system, by suppressing a function of immune cells by suppressing proliferation of activated T cells or suppressing production of interferon alpha (IFN-α) by activated plasmacytoid dendritic cells (pDC), particularly an autoimmune disease such as systemic lupus erythematosus (SLE) and lupus nephritis in SLE patients. The present invention provides a compound represented by general formula (I) : [wherein X, R1, R2, R3, R4, R5 and R6 are as described in the description], or a pharmaceutically acceptable salt thereof.
Inventors:
Hiroshi Maruoka
Toshiharu Noji
Hidenobu Murafuji
Tomoyuki Tsunefuka
Junko Takahashi
Shuhei Uesugi
Rei Tomita
Toshiharu Noji
Hidenobu Murafuji
Tomoyuki Tsunefuka
Junko Takahashi
Shuhei Uesugi
Rei Tomita
Application Number:
JP2020523164A
Publication Date:
July 21, 2023
Filing Date:
June 06, 2019
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C07D205/04; A61K31/397; A61K31/422; A61K31/427; A61K31/4427; A61K31/5377; A61P1/04; A61P9/00; A61P11/00; A61P13/12; A61P17/06; A61P21/00; A61P25/00; A61P37/02; A61P43/00; C07D401/04; C07D401/12; C07D405/12; C07D413/12; C07D417/04
Domestic Patent References:
| JP2016535003A | ||||
| JP2015523981A | ||||
| JP2009114108A |
Foreign References:
| WO2015089143A1 | ||||
| WO2015124591A1 |
Attorney, Agent or Firm:
Kimi Ishibashi
Noriko Kitano
Toshiyasu Takemoto
Noriko Kitano
Toshiyasu Takemoto