Title:
酸増強抗細菌効力を有するアゾ型第四級ピリジニウム塩、それらの使用方法、合成方法、および使用
Document Type and Number:
Japanese Patent JP6857723
Kind Code:
B2
Abstract:
A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH=5); in neutral or basic conditions, this new Azo-QPS shows a much lower level (2-50 times less) anti-bacterial activity. The use of such a “stimulus-enhance” antibiotic can response to the proliferation of bacteria directly. It helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. The antibacterial properties of Azo-QPS are “activated” when the environmental pH becomes acidic; this acidic pH may be indicative of the accumulation of Streptococcus mutans, or the initiation of tooth decay.
Inventors:
Sun, Jirung
Application Number:
JP2019520429A
Publication Date:
April 14, 2021
Filing Date:
October 05, 2017
Export Citation:
Assignee:
AD Foundation
International Classes:
C07D213/76; A61K31/655; A61P31/04; G01N27/327; G01N27/333; G01N27/416; G01N33/53; G01N33/543
Other References:
GARCIA-AMOROS, Jaume et al.,Fast Isomerizing Methyl Iodide Azopyridinium Salts for Molecular Switches,Organic Letters,2010年,vol.12, no.15,pp.3514-3517
ZAPP, Eduardo et al.,Liquid crystal and gold nanoparticles applied to electrochemical immunosensor for cardiac biomarker,Biosensors and Bioelectronics,2014年,vol.59,pp.127-133
ZAPP, Eduardo et al.,Troponin T Immunosensor Based on Liquid Crystal and Silsesquioxane-Supported Gold Nanoparticles,Bioconjugate Chemistry,2014年 8月11日,vol.25, no.9,pp.1638-1643
ZAPP, Eduardo et al.,Liquid crystal and gold nanoparticles applied to electrochemical immunosensor for cardiac biomarker,Biosensors and Bioelectronics,2014年,vol.59,pp.127-133
ZAPP, Eduardo et al.,Troponin T Immunosensor Based on Liquid Crystal and Silsesquioxane-Supported Gold Nanoparticles,Bioconjugate Chemistry,2014年 8月11日,vol.25, no.9,pp.1638-1643
Attorney, Agent or Firm:
Hidekazu Miyoshi
Masakazu Ito
Yuko Hara
Masakazu Ito
Yuko Hara