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Title:
BENZ[a]ANTHRACENE-1,7,12-TRIONE DERIVATIVE
Document Type and Number:
Japanese Patent JP2001019656
Kind Code:
A
Abstract:

To obtain the subject new compound useful as medicaments, especially as a medicinal agent against Helicobacter pylori of pathogenic bacterium reported to be a pathogenic background factor of digestive ulcer, inflammation, upper digestive canal disease etc.

This new compound is a benz[a]anthracene-1,7,12-trione compound of the formula, and is obtained by culturing bacteria belonging to Streptomyces and producing the above compound, e.g. Streptomyces sp. Q 57,219 strain, preferably in a nutrient medium showing pH value of 4 to 9 at 15-37°C for 1-30 days, by adding e.g. an organic solvent to the culture filtrate or body cells and by extraction. Since known products, Ochromycinone, Tetrangomycin and Fujianmycin A, are also produced and have activity against Helicobacter pylori, those including the above new compound can be utilized as effective ingredients for a medicinal agent against Helicobacter pylori.


Inventors:
TANIGUCHI MASATOSHI
NAGAI KOJI
WATANABE MASATO
MATSUMOTO HISAO
Application Number:
JP18979599A
Publication Date:
January 23, 2001
Filing Date:
July 02, 1999
Export Citation:
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Assignee:
YAMANOUCHI PHARMA CO LTD
International Classes:
A61K31/00; A61K31/12; A61K31/122; A61P31/00; A61P31/04; C07C50/38; (IPC1-7): C07C50/38; A61K31/00; A61K31/12
Attorney, Agent or Firm:
Shozo Nagai (2 outside)



 
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