To obtain the subject new compound useful as medicaments, especially as a medicinal agent against Helicobacter pylori of pathogenic bacterium reported to be a pathogenic background factor of digestive ulcer, inflammation, upper digestive canal disease etc.
This new compound is a benz[a]anthracene-1,7,12-trione compound of the formula, and is obtained by culturing bacteria belonging to Streptomyces and producing the above compound, e.g. Streptomyces sp. Q 57,219 strain, preferably in a nutrient medium showing pH value of 4 to 9 at 15-37°C for 1-30 days, by adding e.g. an organic solvent to the culture filtrate or body cells and by extraction. Since known products, Ochromycinone, Tetrangomycin and Fujianmycin A, are also produced and have activity against Helicobacter pylori, those including the above new compound can be utilized as effective ingredients for a medicinal agent against Helicobacter pylori.
NAGAI KOJI
WATANABE MASATO
MATSUMOTO HISAO