Title:
ＢＲＡＧ２阻害剤とその適用
Document Type and Number:
Japanese Patent JP2021530519
Kind Code:
A
Abstract:
本発明は、以下の化学構造（I）：を有する分子に関する。本発明は、特にBRAG2阻害剤として活性な分子とその適用に関する。特に、本発明は、癌又は血管新生の処置におけるBRAG2阻害剤に関する。
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Inventors:
Mael Zegoof
Rafael Rodriguez
Jacqueline Shephis
Agata Nowrotech
Sara Benabudi
Spapoln Nyomcheon
Rafael Rodriguez
Jacqueline Shephis
Agata Nowrotech
Sara Benabudi
Spapoln Nyomcheon
Application Number:
JP2021502501A
Publication Date:
November 11, 2021
Filing Date:
July 16, 2019
Export Citation:
Assignee:
Center Nacional de la Russier Che Scientific
International Classes:
A61K31/352; A61P35/00; A61P43/00; C07D311/22
Domestic Patent References:
| JP2007097421A | 2007-04-19 | |||
| JP2002542187A | 2002-12-10 |
Foreign References:
| WO2009026657A1 | 2009-03-05 | |||
| WO2015010032A1 | 2015-01-22 | |||
| WO2012170371A1 | 2012-12-13 |
Other References:
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SOSNOVKIKH, V. Y. AND USACHEV, B.I: "2-(Polyfluoroalkyl )chromones. 13. Synthesis and nitration of 6,8-dibromo-2-(trifluoromethyl)chromon", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 51, no. 10, JPN6023017621, 2002, pages 1954 - 1956, ISSN: 0005186182
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SOSNOVSKIKH, V. AND USACHEV, B. I.: "2-Polyfluoroalkylchromones. 6. Synthesis of substituted 2-morpholino-2-trifluoromethylchroman-4-ones", RUSSIAN CHEMICAL BULLETIN, vol. 50, JPN6023017608, 2001, pages 453 - 455, ISSN: 0005186184
KHARRAT, S. E. ET AL.: "Synthesis of 3-Trifluoromethyl- and 3-Perfluoroalkyl-Substituted 3-Aryloxy- and 3-Heteroaryloxyprope", SYNTHESIS, vol. 22, JPN6023017609, 2007, pages 3542 - 3552, ISSN: 0005186185
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KHILYA, V. P. ET AL.: "Synthesis and properties of heterocyclic analogs of isoflavones", KHIMIA GETEROCIKICHESKIH SOEDINENII, vol. 9, JPN6023017611, 1973, pages 1202 - 1208, XP009510591, ISSN: 0005186187, DOI: 10.1007/BF00474779
BONDARENKO, S. P. ET AL.: "Synthesis of Analogs of Natural Isoflavonoids Containing Phloroglucinol", CHEMISTRY OF NATURAL COMPOUNDS (TRANSLATION OF KHIMIYA PRIRODNYKH SOEDINENII), vol. 39, no. 3, JPN6023017616, 2003, pages 271 - 275, XP055544860, ISSN: 0005052936, DOI: 10.1023/A:1025422502712
SOSNOVSKIKH, V. Y. ET AL.: "Regioselective Nucleophilic 1,4-Trifluoromethylation of 2- STN-1-L8-18 Polyfluoroalkylchromones with", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 20, JPN6023017617, 2003, pages 7747 - 7754, ISSN: 0005052937
TAMURA, K. ET AL.: "Synthesis of 2-polyfluoroalkylated thiochromones and chromones", JOURNAL OF FLUORINE CHEMISTRY, vol. 68, no. 1, JPN6023017618, 1994, pages 25 - 31, XP055544700, ISSN: 0005052938, DOI: 10.1016/0022-1139(93)02979-O
SZABO, V. ET AL.: "Synthesis of C3-substituted chromones, V. Synthesis of thiazolyl analogs of isoflavones", MAGYAR KEMIAI FOLYOIRAT, vol. Vo.83, No.6, JPN6023017619, 1977, pages 274 - 277, ISSN: 0005052939
SOSNOVSKIKH, V. Y. ET AL.: "One-pot synthesis of functionalized benzo[c]coumarins and their precursors via the reaction of 2-(po", RSC ADV., vol. 6, JPN6023017614, 2016, pages 58188 - 58202, XP055544856, ISSN: 0005186188, DOI: 10.1039/C6RA12492E
SOSNOVKIKH, V. Y. AND USACHEV, B.I: "2-(Polyfluoroalkyl )chromones. 13. Synthesis and nitration of 6,8-dibromo-2-(trifluoromethyl)chromon", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 51, no. 10, JPN6023017621, 2002, pages 1954 - 1956, ISSN: 0005186182
SCHEPETKIN, I. A. ET AL.: "Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones", BIOCHEMICAL PHARMACOLOGY, vol. 92, JPN6023017606, 2014, pages 627 - 641, XP055544739, ISSN: 0005186183, DOI: 10.1016/j.bcp.2014.09.027
SOSNOVSKIKH, V. AND USACHEV, B. I.: "2-Polyfluoroalkylchromones. 6. Synthesis of substituted 2-morpholino-2-trifluoromethylchroman-4-ones", RUSSIAN CHEMICAL BULLETIN, vol. 50, JPN6023017608, 2001, pages 453 - 455, ISSN: 0005186184
KHARRAT, S. E. ET AL.: "Synthesis of 3-Trifluoromethyl- and 3-Perfluoroalkyl-Substituted 3-Aryloxy- and 3-Heteroaryloxyprope", SYNTHESIS, vol. 22, JPN6023017609, 2007, pages 3542 - 3552, ISSN: 0005186185
WANG, LI ET AL.: "Synthesis, Crystal Structure, and Biological Evaluation of a Series of Phloretin Derivatives", MOLECULES, vol. 19, JPN6023017610, 2014, pages 16447 - 16457, XP055544744, ISSN: 0005186186, DOI: 10.3390/molecules191016447
KHILYA, V. P. ET AL.: "Synthesis and properties of heterocyclic analogs of isoflavones", KHIMIA GETEROCIKICHESKIH SOEDINENII, vol. 9, JPN6023017611, 1973, pages 1202 - 1208, XP009510591, ISSN: 0005186187, DOI: 10.1007/BF00474779
BONDARENKO, S. P. ET AL.: "Synthesis of Analogs of Natural Isoflavonoids Containing Phloroglucinol", CHEMISTRY OF NATURAL COMPOUNDS (TRANSLATION OF KHIMIYA PRIRODNYKH SOEDINENII), vol. 39, no. 3, JPN6023017616, 2003, pages 271 - 275, XP055544860, ISSN: 0005052936, DOI: 10.1023/A:1025422502712
SOSNOVSKIKH, V. Y. ET AL.: "Regioselective Nucleophilic 1,4-Trifluoromethylation of 2- STN-1-L8-18 Polyfluoroalkylchromones with", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 20, JPN6023017617, 2003, pages 7747 - 7754, ISSN: 0005052937
TAMURA, K. ET AL.: "Synthesis of 2-polyfluoroalkylated thiochromones and chromones", JOURNAL OF FLUORINE CHEMISTRY, vol. 68, no. 1, JPN6023017618, 1994, pages 25 - 31, XP055544700, ISSN: 0005052938, DOI: 10.1016/0022-1139(93)02979-O
SZABO, V. ET AL.: "Synthesis of C3-substituted chromones, V. Synthesis of thiazolyl analogs of isoflavones", MAGYAR KEMIAI FOLYOIRAT, vol. Vo.83, No.6, JPN6023017619, 1977, pages 274 - 277, ISSN: 0005052939
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura