Title:
BACTERIAL PHEROMONE AND USE THEREOF
Document Type and Number:
Japanese Patent JP2010011852
Kind Code:
A
Abstract:
To provide a new class of pheromones which stimulate the resuscitation of bacteria after dormancy or resuscitation factor (RP-factor) which may exhibit activity at picomolar concentration since the latent states of pathogenic bacteria become serious medical issues.
RP-factors, their cognate receptors, convertases, respective genes and inhibitors or mimetics thereof are described. In particular, antibodies, pharmaceutical compositions and therapeutic and diagnostic methods based on the RP-factors and their receptors/convertases are described.
Inventors:
MUKAMOLOVA GALINA V
KAPRELYANTS ARSENY S
YOUNG DANIELLE I
KELL DOUGLAS B
YOUNG MICHAEL
KAPRELYANTS ARSENY S
YOUNG DANIELLE I
KELL DOUGLAS B
YOUNG MICHAEL
Application Number:
JP2009180965A
Publication Date:
January 21, 2010
Filing Date:
August 03, 2009
Export Citation:
Assignee:
ABERYSTWYTH UNIV
International Classes:
C12N15/09; A61K38/00; A61K39/02; A61K39/04; A61K39/395; A61K45/00; A61P31/04; C07K14/195; C07K14/305; C07K14/31; C07K14/315; C07K14/32; C07K14/33; C07K14/335; C07K14/34; C07K14/35; C07K14/36; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N1/38; C12N5/10; C12N15/31; C12Q1/68; A61K39/00; C12R1/32; A61K; C07K; C12N; C12Q; G01N
Other References:
JPN6008025233; Ｄａｔａｂａｓｅ ＤＤＢＪ／ＥＭＢＬ／ＧｅｎＢａｎｋ ［ｏｎｌｉｎｅ］， Ａｃｃｅｓｓｉｏｎ Ｎｏ．Ｚ８１３６８: ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｅｎｔｒｅｚ／ｖｉｅｗｅｒ．ｆｃｇｉ？１６５５６３９：ＯＬＤＩＤ：２８５１２９６＞ , ３１-ＯＣＴ-１９９６ ｕｐｌｏａｄｅｄ， Ｄｅｖｌｉｎ Ｋ． ｅｔ ａｌ．
JPN6008025235; Ｔｒｅｎｄｓ Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．４， Ｎｏ．６, 199606, ｐ．２３７-２４２
JPN6008025236; ＦＥＭＳ Ｍｉｃｒｏｂｉｏｌ． Ｌｅｔｔ． Ｖｏｌ．１１５， Ｎｏ．２-３, 199401, ｐ．３４７-３５２
JPN6008025232; Ｄａｔａｂａｓｅ ＤＤＢＪ／ＥＭＢＬ／ＧｅｎＢａｎｋ ［ｏｎｌｉｎｅ］， Ａｃｃｅｓｓｉｏｎ Ｎｏ．Ｚ９４７５２: ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｅｎｔｒｅｚ／ｖｉｅｗｅｒ．ｆｃｇｉ？２０５２１２０：ＯＬＤＩＤ：３４３５２４８＞ , ２４-ＡＰＲ-１９９７ ｕｐｌｏａｄｅｄ， Ｍｕｒｐｈｙ Ｌ． ｅｔ ａｌ．
JPN6008025234; Ｄａｔａｂａｓｅ ＤＤＢＪ／ＥＭＢＬ／ＧｅｎＢａｎｋ ［ｏｎｌｉｎｅ］， Ａｃｃｅｓｓｉｏｎ Ｎｏ．Ｄ２６１８５: ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｅｎｔｒｅｚ／ｖｉｅｗｅｒ．ｆｃｇｉ？４６７３２６：ＯＬＤＩＤ：２６４９８５３＞ , ０２-ＳＥＰ-１９９６ ｕｐｌｏａｄｅｄ， Ｏｇａｓａｗａｒａ Ｎ． ｅｔ ａｌ．
JPN6008025235; Ｔｒｅｎｄｓ Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．４， Ｎｏ．６, 199606, ｐ．２３７-２４２
JPN6008025236; ＦＥＭＳ Ｍｉｃｒｏｂｉｏｌ． Ｌｅｔｔ． Ｖｏｌ．１１５， Ｎｏ．２-３, 199401, ｐ．３４７-３５２
JPN6008025232; Ｄａｔａｂａｓｅ ＤＤＢＪ／ＥＭＢＬ／ＧｅｎＢａｎｋ ［ｏｎｌｉｎｅ］， Ａｃｃｅｓｓｉｏｎ Ｎｏ．Ｚ９４７５２: ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｅｎｔｒｅｚ／ｖｉｅｗｅｒ．ｆｃｇｉ？２０５２１２０：ＯＬＤＩＤ：３４３５２４８＞ , ２４-ＡＰＲ-１９９７ ｕｐｌｏａｄｅｄ， Ｍｕｒｐｈｙ Ｌ． ｅｔ ａｌ．
JPN6008025234; Ｄａｔａｂａｓｅ ＤＤＢＪ／ＥＭＢＬ／ＧｅｎＢａｎｋ ［ｏｎｌｉｎｅ］， Ａｃｃｅｓｓｉｏｎ Ｎｏ．Ｄ２６１８５: ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｅｎｔｒｅｚ／ｖｉｅｗｅｒ．ｆｃｇｉ？４６７３２６：ＯＬＤＩＤ：２６４９８５３＞ , ０２-ＳＥＰ-１９９６ ｕｐｌｏａｄｅｄ， Ｏｇａｓａｗａｒａ Ｎ． ｅｔ ａｌ．
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Takeyasu Ito
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Takeyasu Ito