Title:
Base part protection oligonucleotide
Document Type and Number:
Japanese Patent JP6237237
Kind Code:
B2
Abstract:
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3'-position.
Inventors:
Kunihiro Hirai
Satoshi Katayama
Torii Takayoshi
Ryotaro Nakatani
Daisuke Takahashi
Satoshi Katayama
Torii Takayoshi
Ryotaro Nakatani
Daisuke Takahashi
Application Number:
JP2013558763A
Publication Date:
November 29, 2017
Filing Date:
February 15, 2013
Export Citation:
Assignee:
AJINOMOTO CO.,LTD.
International Classes:
C07H19/073; C07H19/173; C07H21/00
Domestic Patent References:
| JP2008230985A | ||||
| JP62188970A | ||||
| JP61112093A | ||||
| JP9500398A | ||||
| JP2010275254A | ||||
| JP2016179993A |
Foreign References:
| US20040082774 | ||||
| WO2005070859A1 | ||||
| WO2013179412A1 | ||||
| WO2012157723A1 |
Other References:
BASHKIN J.K. et al.,Journal of Organic Chemistry,1991年,Vol.56,p.3168-76
PIELES U. et al.,Nucleic Acids Research,1990年,Vol.18, No.15,p.4355-60
STN Registry file[online],1997年,RN: 194786-28-2, ED: 02 Oct 1997
S.Yu.Andreev, S.I.Antsypovich, E.M.Volkov, E.A.Romanova, T.Hianik, T.S.Oretskaya,Symthesis of Oligodeoxyribonucleotides Containing Oleylamine Moieties,Russian Journal of Bioorganic Chemistry,2001年,Vol.27, No.3,p.184-190
T.S.Oretskaya, E.A.Romanova, S.Yu.Andreev, S.I.Antsypovich, C.Toth, V.Gajdos, T.Hianik,A novel method of introducing hydrophobic moieties into oligonucleotides for covalent and non-covale,Bioelectrochemistry,2002年,Vol.56, No.1-2,p.47-51
PIELES U. et al.,Nucleic Acids Research,1990年,Vol.18, No.15,p.4355-60
STN Registry file[online],1997年,RN: 194786-28-2, ED: 02 Oct 1997
S.Yu.Andreev, S.I.Antsypovich, E.M.Volkov, E.A.Romanova, T.Hianik, T.S.Oretskaya,Symthesis of Oligodeoxyribonucleotides Containing Oleylamine Moieties,Russian Journal of Bioorganic Chemistry,2001年,Vol.27, No.3,p.184-190
T.S.Oretskaya, E.A.Romanova, S.Yu.Andreev, S.I.Antsypovich, C.Toth, V.Gajdos, T.Hianik,A novel method of introducing hydrophobic moieties into oligonucleotides for covalent and non-covale,Bioelectrochemistry,2002年,Vol.56, No.1-2,p.47-51
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
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