Title:
BCL-2タンパク質ファミリーの抗アポトーシスメンバーと相互作用するベクリン(Beclin)タンパク質のモチーフ、およびその使用
Document Type and Number:
Japanese Patent JP2008532486
Kind Code:
A
Abstract:
Identifying modulators of programmed cell death, comprising interacting the motif of beclin protein and anti-apoptotic member of Bcl-2, Bcl-XL/Bcl-W protein family and detecting the interaction optionally in presence of a compound to be tested, is new. Identifying modulators of programmed dead cells, comprising interacting the motif of beclin protein and anti-apoptotic member of Bcl-2, Bcl-XL/Bcl-W protein family and detecting the interaction optionally in presence of a compound, is new. The motif comprises Gly-Thr-Met-Glu-Asn-Leu-Ser-Arg-Arg-Leu-Lys-Val-Thr-Gly-Asp-Leu-Phe-Asp-Ile-Met-Ser-Gly-Gln-Thr-Asp-Val (SEQ ID NO. 1). Independent claims are included for: (1) a sequence of amino acids comprising (SEQ ID NO. 1); (2) a nucleic acid sequence (SEQ ID NO. 2) encoding the amino acid sequence of (1); (3) a nucleic acid sequence deduced from the genetic code of (SEQ ID NO. 1); (4) a recombinant vector comprising the nucleic acid sequence of (2); (5) a host cell transformed by the vector of (5); (6) a peptide comprising (SEQ ID NO. 1); (7) a peptide encoded by (SEQ ID NO. 2) or the nucleic acid sequence of (3); (5) a pharmaceutical composition comprising the peptide of (6) or (7). ACTIVITY : Cytostatic; Apoptotic. No biological data given. MECHANISM OF ACTION : None given.
Inventors:
Geneste, Olivier
Hickman, John
Lane, Jean-Christophe
Hickman, John
Lane, Jean-Christophe
Application Number:
JP2007553643A
Publication Date:
August 21, 2008
Filing Date:
January 31, 2006
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
C12Q1/00; A61K38/00; A61P35/00; A61P43/00; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; G01N33/542; G01N21/78
Foreign References:
| WO2000053808A1 | 2000-09-14 | |||
| WO1998011256A1 | 1998-03-19 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito