Title:
ベンゾラクタム化合物
Document Type and Number:
Japanese Patent JP6931646
Kind Code:
B2
Abstract:
The invention provides a compound of formula (0):or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein:n is 1 or 2;X is CH or N;Y is selected from CH and C—F;Z is selected from C—Rz and N;R1 is selected from:-(Alk1)t-Cyc1; wherein t is 0 or 1;Optionally substituted C1-6 acyclic hydrocarbon groupsR2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms;R3 is hydrogen or a group L1-R7;R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; andR4a is selected from hydrogen and a C1-3 alkyl group;wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein;provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.The compounds are inhibitors of ERK1/2 kinases and will be useful in the treatment of ERK1/2-mediated conditions. The compounds are therefore useful in therapy, in particular in the treatment of cancer.
Inventors:
Valerio, Berdini
Ildico, maria, back
James, Edward, Harvey, Day
Charlotte, Mary, Griffith-Jones
Thomas, Daniel, Heightman
Steven, Howard
Christopher, William, Marie
David, Norton
Mark, O'Reilly
Allison, Jo-Anne, Woolford
Michael, Liam, Cook
David, Cousin
Stuart, Thomas, Onions
Jonathan, Martin, Shannon
John, Paul, Watts
Ildico, maria, back
James, Edward, Harvey, Day
Charlotte, Mary, Griffith-Jones
Thomas, Daniel, Heightman
Steven, Howard
Christopher, William, Marie
David, Norton
Mark, O'Reilly
Allison, Jo-Anne, Woolford
Michael, Liam, Cook
David, Cousin
Stuart, Thomas, Onions
Jonathan, Martin, Shannon
John, Paul, Watts
Application Number:
JP2018519702A
Publication Date:
September 08, 2021
Filing Date:
October 20, 2016
Export Citation:
Assignee:
Otsuka Pharmaceutical Co., Ltd.
International Classes:
C07D401/14; A61K31/444; A61K31/4725; A61K31/496; A61K31/506; A61K31/519; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/553; A61K45/00; A61P35/00; A61P43/00; C07D209/46; C07D403/04; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D451/02; C07D453/06; C07D471/04; C07D487/04; C07D493/08; C07D513/04; C07F5/04
Domestic Patent References:
| JP2013516402A | ||||
| JP2012512888A | ||||
| JP2012502029A | ||||
| JP2013515786A |
Foreign References:
| WO2015108861A1 | ||||
| US20130065897 | ||||
| US20100267712 |
Other References:
STN International,file REGISTRY [online],[令和2年6月2日検索],CAS Registry No. 1531591-69-1(Entered STN: 27 Jan 2014), 1489260-76-5, 1489260-74-3, 1489260-72-1, 1489260-63-0, 1489260-27-6, 1489259-62-2, 1489253-27-1, 1489251-89-9, 1489250-39-6, 1489248-51-2, 1489247-85-9, 1489247-84-8, 1489247-78-0, 1489247-57-5, 1489247-50-8, 1489247-46-2, 1489247-40-6, 1489247-36-0, 1489246-81-2, 1489246-79-8, 1489246-77-6, 1489246-55-0, 1489245-96-6, 1489235-18-8, 1489235-17-7, 1489234-85-6, 1489234-79-8
Attorney, Agent or Firm:
Hiroyuki Nagai
Yukitaka Nakamura
Yasukazu Sato
Satoru Asakura
Mari Asano
Hiroshi Sorimachi
Yukitaka Nakamura
Yasukazu Sato
Satoru Asakura
Mari Asano
Hiroshi Sorimachi