To provide a new benzamide derivative having strong histone deacetylase (HDA) inhibiting action.
The objective compound is expressed by formula I [A is H, a (substituted)phenyl or the like; X is direct bond, a group of formula (CH2)e ((e) is 0-4) or the like; (n) is 0-4; Q is OCNR7 (R7 is H or the like) or the like; R1 is H, a halogen, amino or the like; Y is a group of formula II (Het is a heterocyclic group; R2 is H, a halogen or the like); R3 is amino or OH of a site adjacent to the benzamide bond bonding to the heterocyclic group], e.g. the compound of formula III. The compound of formula I can be produced by the condensation reaction of a compound of formula IV with a compound of formula V (E is amino group protected with protecting group used in the peptide-forming reaction such as t-butoxycarbonyl or nitro or the like) preferably at -20 to +50°C for 0.5-48 hr and the removal of the protecting group to convert to amino group. The objective compound is useful as an agent for the treatment of diseases causing cell proliferation, an agent for increasing the effect of gene therapy, etc.
ISHIBASHI DAIKI
TSUCHIYA KATSUTOSHI
NAKANISHI OSAMU
SAITO AKIKO
MARIKO YUKIYASU
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