Title:
BENZAZEPINES
Document Type and Number:
Japanese Patent JPS5839682
Kind Code:
A
Abstract:
There are presented benzazepines of the formula I wherein either R1 is hydrogen, lower alkyl, 4-pyridyl or the group -(CH2)n-NR6R7 and R2 and R3 together are an additional bond or R1 and R2 together are the oxo group and R3 is hydrogen or lower alkyl, R4 is phenyl, o-halophenyl or 2-pyridyl, R5 is halogen or nitro and either R6 is hydrogen or lower alkyl and R7 is hydrogen, lower alkyl, lower alkenyl or lower alkynyl or R6 and R7 together with the nitrogen atom are 4-(lower alkyl)-1-piperazinyl or 4-morpholinyl and n is the number 0 or 1, and their pharmaceutically acceptable acid additions salts. The compounds possess interesting psychotropic properties, i.e., pronounced anxiolytic properties have been established in the case of certain representative members of this class of substance.
Inventors:
RUNE BORE
MATSUKUSU GERETSUKE
EMIRIO KIBURUTSU
MATSUKUSU GERETSUKE
EMIRIO KIBURUTSU
Application Number:
JP13745282A
Publication Date:
March 08, 1983
Filing Date:
August 09, 1982
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/55; A61P25/20; C07C45/46; C07C51/353; C07C57/58; C07D213/30; C07D213/32; C07D223/16; C07D281/18; C07D401/04; C07D417/04; C07D487/04; C07D513/04; (IPC1-7): A61K31/55; C07D223/16; C07D487/04
Attorney, Agent or Firm:
Heikichi Odashima