Title:
ベンゼン化合物およびその医薬としての用途
Document Type and Number:
Japanese Patent JP3870419
Kind Code:
B2
Abstract:
A benzene compound of the formula wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behçet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
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Inventors:
Tetsuro Fujita
Kunichi Adachi
Toshiyuki Ohara
Masahiro Castle
Kenji Chiba
Koji Teshima
Sanshin Tadashi
Kunichi Adachi
Toshiyuki Ohara
Masahiro Castle
Kenji Chiba
Koji Teshima
Sanshin Tadashi
Application Number:
JP50794296A
Publication Date:
January 17, 2007
Filing Date:
August 22, 1995
Export Citation:
Assignee:
MITSUBISHI PHARMA CORPORATION
International Classes:
C07C215/28; A61K31/135; A61K31/165; A61K31/222; A61P29/00; A61P37/06; C07C215/30; C07C215/56; C07C217/64; C07C217/72; C07C219/22; C07C225/16; C07C233/16; C07C233/18; C07C233/31; C07C233/36; C07C233/73; C07C271/16; C07C271/18
Domestic Patent References:
| JP6100560A | ||||
| JP3232867A | ||||
| JP2085268A | ||||
| JP7097374A | ||||
| JP7228559A |
Foreign References:
| WO1994008943A1 | ||||
| WO1995009160A1 |
Other References:
Bioorganic & Medicinal Chemistry Letters,(1994),4(3),p.491-4
Tetrahedron Letters,(1993),34(50),p.8119-22
Tetrahedron Letters,(1993),34(50),p.8119-22
Attorney, Agent or Firm:
Takashima Ichi