Title:
ベンズイミダゾール-4-カルボキサミド誘導体及びその製造方法、薬物混合物及びその用途
Document Type and Number:
Japanese Patent JP2012514607
Kind Code:
A
Abstract:
The present invention relates to the benzimidazole-4-carboxamide derivatives of Formula (I) or pharmaceutically acceptable salts thereof,
pharmaceutical compositions and their uses.
X represents thienyl monosubstituted by nitro or amino. unsubstituted thienyl;
Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C 1 -C 6 alkylphenyl, phenyl monosubstituted by -F, -Cl, -Br or -I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C 1 -C 6 alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted by C 1 -C 6 alkyl or unsubstituted piperazinyl, pyridyl monosubstituted or bisubstituted or trisubstituted by C 1 -C 6 alkyl or unsubstituted pyridyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted by C 1 -C 6 alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted by C 1 -C 6 alkyl or unsubstituted piperazinyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted by C 1 -C 6 alkyl or unsubstituted pyrrolyl, thiazolyl monosubstituted by C 1 -C 6 alkyl, pyrimidinyl monosubstituted or bisubstituted by C 1 -C 6 alkyl or unsubstituted pyrimidinyl, pyrimidinyl monsubstituted by C 1 -C 6 alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted by C 1 -C 6 alkyl and bisubstituted or trisubstituted by -F, -Cl, -Br or -I, purinyl monosubstituted or bisubstituted by C 1 -C 6 alkyl or unsubstituted purinyl, purinyl monosubstituted by hydroxyl.
Inventors:
Luo, Zanjin
Shwe, Faye
Chan, Chong Grib
Shu, Nai Yun
Shwe, Faye
Chan, Chong Grib
Shu, Nai Yun
Application Number:
JP2011544774A
Publication Date:
June 28, 2012
Filing Date:
January 06, 2010
Export Citation:
Assignee:
Shanghai Jia Tong University
International Classes:
C07D235/08; A61K31/4184; A61K31/427; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/522; A61P31/12; C07D235/12; C07D235/14; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D409/04; C07D409/14; C07D417/04; C07D417/12; C07D417/14; C07D473/02; C07D473/18
Domestic Patent References:
| JP2000509719A | 2000-08-02 | |||
| JP2005509633A | 2005-04-14 | |||
| JP2008533151A | 2008-08-21 | |||
| JPH11513364A | 1999-11-16 |
Foreign References:
| CN1272333C | 2006-08-30 | |||
| WO2006130673A1 | 2006-12-07 | |||
| CN1425663A | 2003-06-25 | |||
| WO2008100376A2 | 2008-08-21 |
Other References:
JPN6013052597; ＣＨＥＮＧ ＪＵＮ． ＥＴ ＡＬ: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．１５， Ｎｏ．２, 2005, ｐｐ２６７-２６９
JPN6013052599; ＤＥＮＮＹ ＷＩＬＬＩＡＭ Ａ． ＥＴ ＡＬ: ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３３， Ｎｏ．２, 1990, ｐｐ８１４-８１９
JPN6013052601; Ｏ' ＣＯＮＮＯＲ ＣＨＡＲＭＩＡＮ Ｊ． ＥＴ ＡＬ: ＣＨＥＭ-ＢＩＯＬ． ＩＮＴＥＲＡＣＴＩＯＮＳ Ｖｏｌ．７５， Ｎｏ．Ｌ, 1990, ｐｐ９３-１０４
JPN6013052602; ＣＥＣＣＡＲＥＬＬＩ ＥＴ ＡＬ: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．１７， Ｎｏ．５, 2007, ｐｐ１３０２-１３０６
JPN6013052599; ＤＥＮＮＹ ＷＩＬＬＩＡＭ Ａ． ＥＴ ＡＬ: ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３３， Ｎｏ．２, 1990, ｐｐ８１４-８１９
JPN6013052601; Ｏ' ＣＯＮＮＯＲ ＣＨＡＲＭＩＡＮ Ｊ． ＥＴ ＡＬ: ＣＨＥＭ-ＢＩＯＬ． ＩＮＴＥＲＡＣＴＩＯＮＳ Ｖｏｌ．７５， Ｎｏ．Ｌ, 1990, ｐｐ９３-１０４
JPN6013052602; ＣＥＣＣＡＲＥＬＬＩ ＥＴ ＡＬ: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．１７， Ｎｏ．５, 2007, ｐｐ１３０２-１３０６
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Nao Oda