第Xa因子阻害剤としてのベンゾイミダゾール誘導体 - Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung

Title:

第Xa因子阻害剤としてのベンゾイミダゾール誘導体

Document Type and Number:

Japanese Patent JP4658940

Kind Code:

B2

Abstract:

Benzimidazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I, wherein R<0> ; R<1> ; R<2> ; R<3> ; R<4>; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

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Inventors:

Marc Nazareth
Michael Wagner
Volkmar Weener
Hans Matter
Matthias Wooman
Kurt Ritter

Application Number:

JP2006529739A

Publication Date:

March 23, 2011

Filing Date:

May 05, 2004

Export Citation:

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Assignee:

Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung

International Classes:

C07D401/12; A61K31/422; A61K31/437; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61K31/506; A61K31/522; A61K31/5377; A61K31/541; A61K31/553; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P29/00; A61P31/04; A61P31/12; A61P35/00; C07D235/24; C07D235/30; C07D401/14; C07D403/12; C07D409/14; C07D413/12; C07D413/14; C07D417/14; C07D471/04; C07D471/08; C07D473/08; C07D495/04

Domestic Patent References:

JP63146871A
JP9124609A
JP10182459A

Attorney, Agent or Firm:

Chika Takagi
Junji Yuda
Shoji Miwa

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