Title:
BENZIMIDAZOLES AS PROLYLHYDROXYLASE INHIBITORS
Document Type and Number:
Japanese Patent JP2018065841
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide potent prolylhydroxylase modulators with desirable pharmaceutical properties.SOLUTION: The present invention provides a benzimidazole compound of formula (I), and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. (R1's independently represent C1-4 alkyl, C1-4 alkylsulfonyl, C1-4 alkylsulfinyl, C1-4 alkylsulfanyl, NO2, NH2, NH-C1-4 alkyl, NH-SO2-C1-4 alkyl, NH-(O)-C1-4 alkyl, CN, CO2H, OC1-4 alkyl, NH-(CH2) 2-morpholine, NH(CO) CH2-morpholine, NHC(O)-CH2-piperidine, NHC(O)-CH2-(N-methylpiperazine), NH-C1-4 alkyl -morpholine, pyrrolidine, piperidine and morpholine or the like; R2 and R3 are H; each Z is C, provided that when there are two Z's, they are N.SELECTED DRAWING: None
Inventors:
FRANCES MEREDITH HOCUTT
BARRY EASTMAN LEONARD
HILLARY M PELTIER
VICTOR K PHUONG
MICHAEL H RABINOWITZ
MARK D ROSEN
KYLE T TARANTINO
HARIHARAN VENKATESAN
LUCY XIUMIN ZHAO
BARRY EASTMAN LEONARD
HILLARY M PELTIER
VICTOR K PHUONG
MICHAEL H RABINOWITZ
MARK D ROSEN
KYLE T TARANTINO
HARIHARAN VENKATESAN
LUCY XIUMIN ZHAO
Application Number:
JP2017229865A
Publication Date:
April 26, 2018
Filing Date:
November 30, 2017
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV
International Classes:
C07D403/04; A61K31/4178; A61K31/4184; A61K31/429; A61K31/454; A61K31/4738; A61K31/4965; A61K31/5025; A61K31/52; A61K31/5377; A61P1/04; A61P3/04; A61P3/10; A61P7/06; A61P9/00; A61P9/10; A61P17/02; A61P19/08; A61P31/04; C07D471/04; C07D487/04; C07D513/04; C12N9/99
Domestic Patent References:
| JP6022769B2 | 2016-11-09 | |||
| JP2002504546A | 2002-02-12 |
Foreign References:
| WO2007039297A1 | 2007-04-12 | |||
| WO2006114213A1 | 2006-11-02 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Koichi Iwata
Yasuhito Suzuki
Eiji Katayama
Junko Kobayashi
Norio Omori
Koichi Iwata
Yasuhito Suzuki