Title:
ヒトORL1受容体に対するアゴニストとしてのベンズイミダゾロン及びキナゾリノン誘導体
Document Type and Number:
Japanese Patent JP2007506709
Kind Code:
A
Abstract:
The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1): wherein the symbols have the meanings as given in the description.
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Inventors:
Den Hull Talk, Jacobs AJ
Van Schialenburg, Gustav J.A.M.
Steuweenberg, Hermann H.
Toinstra, Theinka
Telbstra, Jan-Willem
Van Schialenburg, Gustav J.A.M.
Steuweenberg, Hermann H.
Toinstra, Theinka
Telbstra, Jan-Willem
Application Number:
JP2006527416A
Publication Date:
March 22, 2007
Filing Date:
September 23, 2004
Export Citation:
Assignee:
Solvay Pharmaceuticals B.V.
International Classes:
C07D401/04; A61K31/4184; A61K31/454; A61K31/517; A61P1/00; A61P1/04; A61P3/04; A61P7/02; A61P7/06; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/02; A61P13/12; A61P17/00; A61P25/00; A61P25/04; A61P25/14; A61P25/22; A61P25/24; A61P25/28; A61P27/06; A61P31/12; A61P37/00; C07C251/20; C07D403/04; C07D451/04
Attorney, Agent or Firm:
Heikichi Odashima