NEW MATERIAL:A compound expressed by formula I (R1 is phenyl, halogen- substituted phenyl or lower alkyl-substituted phenyl; R2 is H or halogen; R3 is lower alkyl) and nontoxic salt thereof.
EXAMPLE: 6-[3-(tert-Butylamino)-2-hydroxypropoxy]-7-chloro-3-(2-methylphenyl)-1, 2-benzisoxazole.
USE: A medicine, e.g. remedy for edema, hypertension, hyperuricemia, etc., having uric acid discharging action and diuretic action together as well as hypotensive action and hardly causing side effect on the liver.
PREPARATION: A compound expressed by formula II is reacted with a compound expressed by formula III (X is halogen), preferably in an inert solvent in the presence of base at 0W150°C to give a compound expressed by formula IV, which is then reacted with an alkylamine expressed by the formula R3-NH2 in an inert solvent at 0W150°C to afford the aimed compound expressed by formula I.
AOKI BUNYA
SATO HARUHIKO
DAN TAKASHI
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