NEW MATERIAL: A compd. represented by formula I [wherein X is CH2, O or S, R1 and R2 are alkyl or combined to form (CH2)4-5'R3 and R4 are H,F,Cl,N, N-dialkylamino, alkyl or phenyl, R5 and R6 are H, F, Br, alkyl or alkoxy, R7 and R8 are H or form a trans-type double bond together with a C-C bond, R9 and R10 are H or combined to form dialkylmethylene and R11 is a free acid, ester or amide along with linked CO].
EXAMPLE: (+,-)ethyl 6E-erythro-7-[4-(4-fluorophenyl)-3-spiro(2,1'-cyclopentyl-2H-1- benzopyrane)]-3,5-dihydroxyhepto-6-enoate.
USE: A medicine for hypocholesterolemia and having antithrombotic and antibacterial characteristics.
PROCESS: For example, a keto ester represented by formula II is reduced and, according to circumstances, subjected to transestrification and hydrolysis to obtain the compd. represented by formula I.
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