Title:
ＳＴＩＮＧアゴニストとしてのベンゾ［ｂ］チオフェン化合物
Document Type and Number:
Japanese Patent JP6636673
Kind Code:
B2
Abstract:
Compounds of general formula (Ia), compounds of general formula (Ia′), compounds of general formula (Ib), compounds of general formula (Ib′), compounds of general formula (I), compounds of general formula (I′), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
Inventors:
Altman, Michael, Day
Cash, brandon, day
Chan, Wonsk
Cumming, Jared N
Heydle, Andrew M
Henderson, Timothy Jay
Jewel, jamie pee
Larsen, Matthew A
Rian, Louis
Rim, Jong Won
Liu, Min
Otte, Ryan Dee
Shu, Tony
Trotter, Benjamin Wesley
Tia Grajan, Sri Ram
Cash, brandon, day
Chan, Wonsk
Cumming, Jared N
Heydle, Andrew M
Henderson, Timothy Jay
Jewel, jamie pee
Larsen, Matthew A
Rian, Louis
Rim, Jong Won
Liu, Min
Otte, Ryan Dee
Shu, Tony
Trotter, Benjamin Wesley
Tia Grajan, Sri Ram
Application Number:
JP2019517943A
Publication Date:
January 29, 2020
Filing Date:
October 02, 2017
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D333/60; A61K31/381; A61K31/385; A61K31/424; A61P35/00; A61P37/04; C07D333/62; C07D333/64; C07D333/66; C07D409/12; C07D498/04
Domestic Patent References:
| JP2085281A |
Foreign References:
| WO2016145102A1 | ||||
| WO2016120305A1 | ||||
| WO2015077354A1 | ||||
| WO2019027857A1 | ||||
| WO2019027858A1 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama