Title:
BENZODIOXANE DERIVATIVE
Document Type and Number:
Japanese Patent JPH05230059
Kind Code:
A
Abstract:
PURPOSE: To provide a new compd. useful as an antianxiety drug, antidepressant, neuroleptic, antihypertensive, etc.
CONSTITUTION: This compd. is expressed by formula I, wherein B is (substd.) indol-3-yl, benzimidazol-1-yl; Q is CnH2n; n is 1 to 6. The compd. is, for example, 6-[4-(4-(benzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane. The compd. of formula I is obtd. by allowing a compd. expressed by formula II [X1 is NH2, X (Cl, Br, etc.)], to react with a compd. expressed by formula III (X2, X3 are each X when X1 is NH2, and otherwise, X2, X3 are each NH) in a solvent such as benzene in the presence of a base such as triethylamine.
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Inventors:
HENINGU BOETEIHIYAA
KURISUTOFU ZAIFURIITO
HARUTOMUUTO GURAINAA
GERUTO BARUTOSHIIKU
KURISUTOFU ZAIFURIITO
HARUTOMUUTO GURAINAA
GERUTO BARUTOSHIIKU
Application Number:
JP22148792A
Publication Date:
September 07, 1993
Filing Date:
August 20, 1992
Export Citation:
Assignee:
MERCK PATENT GMBH
International Classes:
A61K31/357; A61K31/496; A61K31/495; A61P9/02; A61P9/08; A61P9/10; A61P9/12; A61P25/00; A61P25/04; A61P25/20; A61P25/24; A61P25/26; A61P25/28; A61P35/00; C07D405/04; C07D405/12; C07D405/14; C07D453/02; (IPC1-7): A61K31/495; C07D405/12
Attorney, Agent or Firm:
Wakabayashi Tadashi