NEW MATERIAL:A compound expressed by formula I [R1 is formula II (A1 and A2 are C or N; R3 and R4 are H, hydroxyl group, lower alkoxy, amino, etc.), formula III (A3 is O, S or NH), etc.; n is an integer 1W5; R5 and R6 are H, hydroxyl group or lower alkoxy] and a salt thereof.
EXAMPLE: 2-(Piperonylthio)benzodioxazole.
USE: A medicine and compound useful for preventing and treating hepatopathy.
PREPARATION: A thiol compound expressed by the formula R1-SM (M is H or alkali metal) or a thiolate compound which is an alkali metal substitution product thereof is reacted with a (substituted) benzodioxazolyl lower alkyl halide or sulfonate expressed by formula IV (X1 is halogen or lower alkylsulfonyloxy, etc.) to afford the aimed compound expressed by formula I.
TANAKA AKIHIRO
NISHIKIORI KOJI
IKADAI HIROYUKI
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