NEW MATERIAL:A benzofuran derivative expressed by formula I (R1 is H, lower alkoxy or halogen; either of R2 and R3 is lower alkyl and the other is lower alkyl, phenyl lower alkyl or both link at terminals together with the adjacent N to form a heterocyclic ring group; ring A is substituted or unsubstituted phenyl; Y is O or S; n is 2 or 3) or salt thereof.
EXAMPLE: 2-Phenyl-7-(2-piperidinoethylthiomethyl)benzofuran.oxalate.
USE: Useful as a treating and preventive agent for pollakiuria, having excellent inhibitory action on urination contraction, effective in use as a treating and prophylactic drug for diseases, e.g., nocturnal enuresis or neurogenic bladder, related to contractility ot urinary tract systems, such as urinary bladder and duct, and capable of being orally and parenterally administered.
PREPARATION: For example, a compound expressed by formula II (X1 is reactive residue) is reacted with an amine expressed by formula III to afford the aimed compound expressed by formula l.
OZEKI MASAKATSU
SAIGA YUTAKA
ISHIZUKA TORU
NOSAKA KUNIO
